Many complex systems, including networks, are not static but can display strong fluctuations at various time scales. Characterizing the dynamics in complex networks is thus of the utmost importance in the understanding of these networks and of the dy
namical processes taking place on them. In this article, we study the example of the US airport network in the time period 1990-2000. We show that even if the statistical distributions of most indicators are stationary, an intense activity takes place at the local (`microscopic) level, with many disappearing/appearing connections (links) between airports. We find that connections have a very broad distribution of lifetimes, and we introduce a set of metrics to characterize the links dynamics. We observe in particular that the links which disappear have essentially the same properties as the ones which appear, and that links which connect airports with very different traffic are very volatile. Motivated by this empirical study, we propose a model of dynamical networks, inspired from previous studies on firm growth, which reproduces most of the empirical observations both for the stationary statistical distributions and for the dynamical properties.
Background: The global spread of the severe acute respiratory syndrome (SARS) epidemic has clearly shown the importance of considering the long-range transportation networks in the understanding of emerging diseases outbreaks. The introduction of ext
ensive transportation data sets is therefore an important step in order to develop epidemic models endowed with realism. Methods: We develop a general stochastic meta-population model that incorporates actual travel and census data among 3 100 urban areas in 220 countries. The model allows probabilistic predictions on the likelihood of country outbreaks and their magnitude. The level of predictability offered by the model can be quantitatively analyzed and related to the appearance of robust epidemic pathways that represent the most probable routes for the spread of the disease. Results: In order to assess the predictive power of the model, the case study of the global spread of SARS is considered. The disease parameter values and initial conditions used in the model are evaluated from empirical data for Hong Kong. The outbreak likelihood for specific countries is evaluated along with the emerging epidemic pathways. Simulation results are in agreement with the empirical data of the SARS worldwide epidemic. Conclusions: The presented computational approach shows that the integration of long-range mobility and demographic data provides epidemic models with a predictive power that can be consistently tested and theoretically motivated. This computational strategy can be therefore considered as a general tool in the analysis and forecast of the global spreading of emerging diseases and in the definition of containment policies aimed at reducing the effects of potentially catastrophic outbreaks.
We study metapopulation models for the spread of epidemics in which different subpopulations (cities) are connected by fluxes of individuals (travelers). This framework allows to describe the spread of a disease on a large scale and we focus here on
the computation of the arrival time of a disease as a function of the properties of the seed of the epidemics and of the characteristics of the network connecting the various subpopulations. Using analytical and numerical arguments, we introduce an easily computable quantity which approximates this average arrival time. We show on the example of a disease spread on the world-wide airport network that this quantity predicts with a good accuracy the order of arrival of the disease in the various subpopulations in each realization of epidemic scenario, and not only for an average over realizations. Finally, this quantity might be useful in the identification of the dominant paths of the disease spread.
Metapopulation models describing cities with different populations coupled by the travel of individuals are of great importance in the understanding of disease spread on a large scale. An important example is the Rvachev-Longini model [{it Math. Bios
ci.} {bf 75}, 3-22 (1985)] which is widely used in computational epidemiology. Few analytical results are however available and in particular little is known about paths followed by epidemics and disease arrival times. We study the arrival time of a disease in a city as a function of the starting seed of the epidemics. We propose an analytical Ansatz, test it in the case of a spreading on the world wide air transportation network, and show that it predicts accurately the arrival order of a disease in world-wide cities.
