Clinical trials are a multi-billion dollar industry. One of the biggest challenges facing the clinical trial research community is satisfying Part 11 of Title 21 of the Code of Federal Regulations and ISO 27789. These controls provide audit requireme
nts that guarantee the reliability of the data contained in the electronic records. Context-aware smart devices and wearable IoT devices have become increasingly common in clinical trials. Electronic Data Capture (EDC) and Clinical Data Management Systems (CDMS) do not currently address the new challenges introduced using these devices. The healthcare digital threat landscape is continually evolving, and the prevalence of sensor fusion and wearable devices compounds the growing attack surface. We propose Scrybe, a permissioned blockchain, to store proof of clinical trial data provenance. We illustrate how Scrybe addresses each control and the limitations of the Ethereum-based blockchains. Finally, we provide a proof-of-concept integration with REDCap to show tamper resistance.
Automatic modulation classification (AMC) is of crucial importance for realizing wireless intelligence communications. Many deep learning based models especially convolution neural networks (CNNs) have been proposed for AMC. However, the computation
cost is very high, which makes them inappropriate for beyond the fifth generation wireless communication networks that have stringent requirements on the classification accuracy and computing time. In order to tackle those challenges, a novel involution enabled AMC scheme is proposed by using the bottleneck structure of the residual networks. Involution is utilized instead of convolution to enhance the discrimination capability and expressiveness of the model by incorporating a self-attention mechanism. Simulation results demonstrate that our proposed scheme achieves superior classification performance and faster convergence speed comparing with other benchmark schemes.
Recent years have witnessed a rapid growth of distributed machine learning (ML) frameworks, which exploit the massive parallelism of computing clusters to expedite ML training. However, the proliferation of distributed ML frameworks also introduces m
any unique technical challenges in computing system design and optimization. In a networked computing cluster that supports a large number of training jobs, a key question is how to design efficient scheduling algorithms to allocate workers and parameter servers across different machines to minimize the overall training time. Toward this end, in this paper, we develop an online scheduling algorithm that jointly optimizes resource allocation and locality decisions. Our main contributions are three-fold: i) We develop a new analytical model that considers both resource allocation and locality; ii) Based on an equivalent reformulation and observations on the worker-parameter server locality configurations, we transform the problem into a mixed packing and covering integer program, which enables approximation algorithm design; iii) We propose a meticulously designed approximation algorithm based on randomized rounding and rigorously analyze its performance. Collectively, our results contribute to the state of the art of distributed ML system optimization and algorithm design.
Intra prediction is an essential component in the image coding. This paper gives an intra prediction framework completely based on neural network modes (NM). Each NM can be regarded as a regression from the neighboring reference blocks to the current
coding block. (1) For variable block size, we utilize different network structures. For small blocks 4x4 and 8x8, fully connected networks are used, while for large blocks 16x16 and 32x32, convolutional neural networks are exploited. (2) For each prediction mode, we develop a specific pre-trained network to boost the regression accuracy. When integrating into HEVC test model, we can save 3.55%, 3.03% and 3.27% BD-rate for Y, U, V components compared with the anchor. As far as we know, this is the first work to explore a fully NM based framework for intra prediction, and we reach a better coding gain with a lower complexity compared with the previous work.
We conduct a subjective experiment to compare the performance of traditional image coding methods and learning-based image coding methods. HEVC and VVC, the state-of-the-art traditional coding methods, are used as the representative traditional metho
ds. The learning-based methods used contain not only CNN-based methods, but also a GAN-based method, all of which are advanced or typical. Single Stimuli (SS), which is also called Absolute Category Rating (ACR), is adopted as the methodology of the experiment to obtain perceptual quality of images. Additionally, we utilize some typical and frequently used objective quality metrics to evaluate the coding methods in the experiment as comparison. The experiment shows that CNN-based and GAN-based methods can perform better than traditional methods in low bit-rates. In high bit-rates, however, it is hard to verify whether CNN-based methods are superior to traditional methods. Because the GAN method does not provide models with high target bit-rates, we cannot exactly tell the performance of the GAN method in high bit-rates. Furthermore, some popular objective quality metrics have not shown the ability well to measure quality of images generated by learning-based coding methods, especially the GAN-based one.
In recent years, to sustain the resource-intensive computational needs for training deep neural networks (DNNs), it is widely accepted that exploiting the parallelism in large-scale computing clusters is critical for the efficient deployments of DNN
training jobs. However, existing resource schedulers for traditional computing clusters are not well suited for DNN training, which results in unsatisfactory job completion time performance. The limitations of these resource scheduling schemes motivate us to propose a new computing cluster resource scheduling framework that is able to leverage the special layered structure of DNN jobs and significantly improve their job completion times. Our contributions in this paper are three-fold: i) We develop a new resource scheduling analytical model by considering DNNs layered structure, which enables us to analytically formulate the resource scheduling optimization problem for DNN training in computing clusters; ii) Based on the proposed performance analytical model, we then develop an efficient resource scheduling algorithm based on the widely adopted parameter-server architecture using a sum-of-ratios multi-dimensional-knapsack decomposition (SMD) method to offer strong performance guarantee; iii) We conduct extensive numerical experiments to demonstrate the effectiveness of the proposed schedule algorithm and its superior performance over the state of the art.
Recent works of multi-source domain adaptation focus on learning a domain-agnostic model, of which the parameters are static. However, such a static model is difficult to handle conflicts across multiple domains, and suffers from a performance degrad
ation in both source domains and target domain. In this paper, we present dynamic transfer to address domain conflicts, where the model parameters are adapted to samples. The key insight is that adapting model across domains is achieved via adapting model across samples. Thus, it breaks down source domain barriers and turns multi-source domains into a single-source domain. This also simplifies the alignment between source and target domains, as it only requires the target domain to be aligned with any part of the union of source domains. Furthermore, we find dynamic transfer can be simply modeled by aggregating residual matrices and a static convolution matrix. Experimental results show that, without using domain labels, our dynamic transfer outperforms the state-of-the-art method by more than 3% on the large multi-source domain adaptation datasets -- DomainNet. Source code is at https://github.com/liyunsheng13/DRT.
We investigate the polarons formed by immersing a spinor impurity in a ferromagnetic state of $F=1$ spinor Bose-Einstein condensate. The ground state energies and effective masses of the polarons are calculated in both weak-coupling regime and strong
-coupling regime. In the weakly interacting regime the second order perturbation theory is performed. In the strong coupling regime we use a simple variational treatment. The analytical approximations to the energy and effective mass of the polarons are constructed. Especially, a transition from the mobile state to the self-trapping state of the polaron in the strong coupling regime is discussed. We also estimate the signatures of polaron effects in spinor BEC for the future experiments.
This paper studies learning node representations with GNNs for unsupervised scenarios. We make a theoretical understanding and empirical demonstration about the non-steady performance of GNNs over different graph datasets, when the supervision signal
s are not appropriately defined. The performance of GNNs depends on both the node feature smoothness and the graph locality. To smooth the discrepancy of node proximity measured by graph topology and node feature, we proposed KS2L - a novel graph underline{K}nowledge distillation regularized underline{S}elf-underline{S}upervised underline{L}earning framework, with two complementary regularization modules, for intra-and cross-model graph knowledge distillation. We demonstrate the competitive performance of KS2L on a variety of benchmarks. Even with a single GCN layer, KS2L has consistently competitive or even better performance on various benchmark datasets.
Web technology underpins many interactive mobile applications. However, energy-efficient mobile web interactions is an outstanding challenge. Given the increasing diversity and complexity of mobile hardware, any practical optimization scheme must wor
k for a wide range of users, mobile platforms and web workloads. This paper presents CAMEL , a novel energy optimization system for mobile web interactions. CAMEL leverages machine learning techniques to develop a smart, adaptive scheme to judiciously trade performance for reduced power consumption. Unlike prior work, C AMEL directly models how a given web content affects the user expectation and uses this to guide energy optimization. It goes further by employing transfer learning and conformal predictions to tune a previously learned model in the end-user environment and improve it over time. We apply CAMEL to Chromium and evaluate it on four distinct mobile systems involving 1,000 testing webpages and 30 users. Compared to four state-of-the-art web-event optimizers, CAMEL delivers 22% more energy savings, but with 49% fewer violations on the quality of user experience, and exhibits orders of magnitudes less overhead when targeting a new computing environment.
