Randomness is an unavoidable feature of the intracellular environment due to chemical reactants being present in low copy number. That phenomenon, predicted by Delbruck long ago cite{delbruck40}, has been detected in both prokaryotic cite{elowitz02,c
ai06} and eukaryotic cite{blake03} cells after the development of the fluorescence techniques. On the other hand, developing organisms, e.g. {em D. melanogaster}, exhibit strikingly precise spatio-temporal patterns of protein/mRNA concentrations cite{gregor07b,manu09a,manu09b,boettiger09}. Those two characteristics of living organisms are in apparent contradiction: the precise patterns of protein concentrations are the result of multiple mutually interacting random chemical reactions. The main question is to establish biochemical mechanisms for coupling random reactions so that canalization, or fluctuations reduction instead of amplification, takes place. Here we explore a model for coupling two stochastic processes where the noise of the combined process can be smaller than that of the isolated ones. Such a canalization occurs if, and only if, there is negative covariance between the random variables of the model. Our results are obtained in the framework of a master equation for a negatively self-regulated -- or externally regulated -- binary gene and show that the precise control due to negative self regulation cite{becskei00} is because it may generate negative covariance. Our results suggest that negative covariance, in the coupling of random chemical reactions, is a theoretical mechanism underlying the precision of developmental processes.
We report on the observation of vortex formation in a Bose-Einstein condensate of Rb-87 atoms. Vortices are generated by superimposing an oscillating excitation to the trapping potential introduced by an external magnetic field. For small amplitudes
of the external excitation field we observe a bending of the cloud axis. Increasing the amplitude we observe formation of a growing number of vortices in the sample. Shot-to-shot variations in both vortex number and position within the condensed cloud are observed, probably due to the intrinsic vortex nucleation dynamics. We discuss the possible formation of vortices and anti-vortices in the sample as well as possible mechanisms for vortex nucleation.
A technique is proposed for creating nonground-state Bose-Einstein condensates in a trapping potential by means of the temporal modulation of atomic interactions. Applying a time-dependent spatially homogeneous magnetic field modifies the atomic scat
tering length. An alternating modulation of the scattering length excites the condensate, which, under special conditions, can be transferred to an excited nonlinear coherent mode. It is shown that there occurs a phase-transition-like behavior in the time-averaged population imbalance between the ground and excited states. The application of the suggested technique to realistic experimental conditions is analyzed and it is shown that the considered effect can be realized for experimentally available condensates.
In a trapped Bose-Einstein condensate, subject to the action of an alternating external field, coherent topological modes can be resonantly excited. Depending on the amplitude of the external field and detuning parameter, there are two principally di
fferent regimes of motion, with mode locking and without it. The change of the dynamic regime corresponds to a dynamic phase transition. This transition can be characterized by an effective order parameter defined as the difference between fractional mode populations averaged over the temporal period of oscillations. The behavior of this order parameter, as a function of detuning, pumping amplitude, and atomic interactions is carefully analyzed. A special attention is payed to numerical calculations for the realistic case of a quadrupole exciting field and the system parameters accessible in current experiments.
