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Register a new userICAM: Interpretable Classification via Disentangled Representations and Feature Attribution Mapping
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Feature attribution (FA), or the assignment of class-relevance to different locations in an image, is important for many classification problems but is particularly crucial within the neuroscience domain, where accurate mechanistic models of behaviours, or disease, require knowledge of all features discriminative of a trait. At the same time, predicting class relevance from brain images is challenging as phenotypes are typically heterogeneous, and changes occur against a background of significant natural variation. Here, we present a novel framework for creating class specific FA maps through image-to-image translation. We propose the use of a VAE-GAN to explicitly disentangle class relevance from background features for improved interpretability properties, which results in meaningful FA maps. We validate our method on 2D and 3D brain image datasets of dementia (ADNI dataset), ageing (UK Biobank), and (simulated) lesion detection. We show that FA maps generated by our method outperform baseline FA methods when validated against ground truth. More significantly, our approach is the first to use latent space sampling to support exploration of phenotype variation. Our code will be available online at https://github.com/CherBass/ICAM.
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An important goal of medical imaging is to be able to precisely detect patterns of disease specific to individual scans; however, this is challenged in brain imaging by the degree of heterogeneity of shape and appearance. Traditional methods, based on image registration to a global template, historically fail to detect variable features of disease, as they utilise population-based analyses, suited primarily to studying group-average effects. In this paper we therefore take advantage of recent developments in generative deep learning to develop a method for simultaneous classification, or regression, and feature attribution (FA). Specifically, we explore the use of a VAE-GAN translation network called ICAM, to explicitly disentangle class relevant features from background confounds for improved interpretability and regression of neurological phenotypes. We validate our method on the tasks of Mini-Mental State Examination (MMSE) cognitive test score prediction for the Alzheimers Disease Neuroimaging Initiative (ADNI) cohort, as well as brain age prediction, for both neurodevelopment and neurodegeneration, using the developing Human Connectome Project (dHCP) and UK Biobank datasets. We show that the generated FA maps can be used to explain outlier predictions and demonstrate that the inclusion of a regression module improves the disentanglement of the latent space. Our code is freely available on Github https://github.com/CherBass/ICAM.
Latent factor collaborative filtering (CF) has been a widely used technique for recommender system by learning the semantic representations of users and items. Recently, explainable recommendation has attracted much attention from research community. However, trade-off exists between explainability and performance of the recommendation where metadata is often needed to alleviate the dilemma. We present a novel feature mapping approach that maps the uninterpretable general features onto the interpretable aspect features, achieving both satisfactory accuracy and explainability in the recommendations by simultaneous minimization of rating prediction loss and interpretation loss. To evaluate the explainability, we propose two new evaluation metrics specifically designed for aspect-level explanation using surrogate ground truth. Experimental results demonstrate a strong performance in both recommendation and explaining explanation, eliminating the need for metadata. Code is available from https://github.com/pd90506/AMCF.
We propose a novel interpretable deep neural network for text classification, called ProtoryNet, based on a new concept of prototype trajectories. Motivated by the prototype theory in modern linguistics, ProtoryNet makes a prediction by finding the most similar prototype for each sentence in a text sequence and feeding an RNN backbone with the proximity of each sentence to the corresponding active prototype. The RNN backbone then captures the temporal pattern of the prototypes, which we refer to as prototype trajectories. Prototype trajectories enable intuitive and fine-grained interpretation of the reasoning process of the RNN model, in resemblance to how humans analyze texts. We also design a prototype pruning procedure to reduce the total number of prototypes used by the model for better interpretability. Experiments on multiple public data sets show that ProtoryNet is more accurate than the baseline prototype-based deep neural net and reduces the performance gap compared to state-of-the-art black-box models. In addition, after prototype pruning, the resulting ProtoryNet models only need less than or around 20 prototypes for all datasets, which significantly benefits interpretability. Furthermore, we report a survey result indicating that human users find ProtoryNet more intuitive and easier to understand than other prototype-based methods.
Capturing interpretable variations has long been one of the goals in disentanglement learning. However, unlike the independence assumption, interpretability has rarely been exploited to encourage disentanglement in the unsupervised setting. In this paper, we examine the interpretability of disentangled representations by investigating two questions: where to be interpreted and what to be interpreted? A latent code is easily to be interpreted if it would consistently impact a certain subarea of the resulting generated image. We thus propose to learn a spatial mask to localize the effect of each individual latent dimension. On the other hand, interpretability usually comes from latent dimensions that capture simple and basic variations in data. We thus impose a perturbation on a certain dimension of the latent code, and expect to identify the perturbation along this dimension from the generated images so that the encoding of simple variations can be enforced. Additionally, we develop an unsupervised model selection method, which accumulates perceptual distance scores along axes in the latent space. On various datasets, our models can learn high-quality disentangled representations without supervision, showing the proposed modeling of interpretability is an effective proxy for achieving unsupervised disentanglement.
Recent research has made the surprising finding that state-of-the-art deep learning models sometimes fail to generalize to small variations of the input. Adversarial training has been shown to be an effective approach to overcome this problem. However, its application has been limited to enforcing invariance to analytically defined transformations like $ell_p$-norm bounded perturbations. Such perturbations do not necessarily cover plausible real-world variations that preserve the semantics of the input (such as a change in lighting conditions). In this paper, we propose a novel approach to express and formalize robustness to these kinds of real-world transformations of the input. The two key ideas underlying our formulation are (1) leveraging disentangled representations of the input to define different factors of variations, and (2) generating new input images by adversarially composing the representations of different images. We use a StyleGAN model to demonstrate the efficacy of this framework. Specifically, we leverage the disentangled latent representations computed by a StyleGAN model to generate perturbations of an image that are similar to real-world variations (like adding make-up, or changing the skin-tone of a person) and train models to be invariant to these perturbations. Extensive experiments show that our method improves generalization and reduces the effect of spurious correlations (reducing the error rate of a smile detector by 21% for example).
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