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Register a new userWhere and What? Examining Interpretable Disentangled Representations
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Xinqi Zhu
Publication date
2021
fields
Informatics Engineering
and research's language is
English
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Capturing interpretable variations has long been one of the goals in disentanglement learning. However, unlike the independence assumption, interpretability has rarely been exploited to encourage disentanglement in the unsupervised setting. In this paper, we examine the interpretability of disentangled representations by investigating two questions: where to be interpreted and what to be interpreted? A latent code is easily to be interpreted if it would consistently impact a certain subarea of the resulting generated image. We thus propose to learn a spatial mask to localize the effect of each individual latent dimension. On the other hand, interpretability usually comes from latent dimensions that capture simple and basic variations in data. We thus impose a perturbation on a certain dimension of the latent code, and expect to identify the perturbation along this dimension from the generated images so that the encoding of simple variations can be enforced. Additionally, we develop an unsupervised model selection method, which accumulates perceptual distance scores along axes in the latent space. On various datasets, our models can learn high-quality disentangled representations without supervision, showing the proposed modeling of interpretability is an effective proxy for achieving unsupervised disentanglement.
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Feature attribution (FA), or the assignment of class-relevance to different locations in an image, is important for many classification problems but is particularly crucial within the neuroscience domain, where accurate mechanistic models of behaviours, or disease, require knowledge of all features discriminative of a trait. At the same time, predicting class relevance from brain images is challenging as phenotypes are typically heterogeneous, and changes occur against a background of significant natural variation. Here, we present a novel framework for creating class specific FA maps through image-to-image translation. We propose the use of a VAE-GAN to explicitly disentangle class relevance from background features for improved interpretability properties, which results in meaningful FA maps. We validate our method on 2D and 3D brain image datasets of dementia (ADNI dataset), ageing (UK Biobank), and (simulated) lesion detection. We show that FA maps generated by our method outperform baseline FA methods when validated against ground truth. More significantly, our approach is the first to use latent space sampling to support exploration of phenotype variation. Our code will be available online at https://github.com/CherBass/ICAM.
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