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Register a new userSpatial Variable Selection and An Application to Virginia Lyme Disease Emergence
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Added by
Yili Hong
Publication date
2018
fields
Mathematical Statistics
and research's language is
English
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Lyme disease is an infectious disease that is caused by a bacterium called Borrelia burgdorferi sensu stricto. In the United States, Lyme disease is one of the most common infectious diseases. The major endemic areas of the disease are New England, Mid-Atlantic, East-North Central, South Atlantic, and West North-Central. Virginia is on the front-line of the diseases diffusion from the northeast to the south. One of the research objectives for the infectious disease community is to identify environmental and economic variables that are associated with the emergence of Lyme disease. In this paper, we use a spatial Poisson regression model to link the spatial disease counts and environmental and economic variables, and develop a spatial variable selection procedure to effectively identify important factors by using an adaptive elastic net penalty. The proposed methods can automatically select important covariates, while adjusting for possible spatial correlations of disease counts. The performance of the proposed method is studied and compared with existing methods via a comprehensive simulation study. We apply the developed variable selection methods to the Virginia Lyme disease data and identify important variables that are new to the literature. Supplementary materials for this paper are available online.
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Lyme disease is a rapidly growing illness that remains poorly understood within the medical community. Critical questions about when and why patients respond to treatment or stay ill, what kinds of treatments are effective, and even how to properly diagnose the disease remain largely unanswered. We investigate these questions by applying machine learning techniques to a large scale Lyme disease patient registry, MyLymeData, developed by the nonprofit LymeDisease.org. We apply various machine learning methods in order to measure the effect of individual features in predicting participants answers to the Global Rating of Change (GROC) survey questions that assess the self-reported degree to which their condition improved, worsened, or remained unchanged following antibiotic treatment. We use basic linear regression, support vector machines, neural networks, entropy-based decision tree models, and $k$-nearest neighbors approaches. We first analyze the general performance of the model and then identify the most important features for predicting participant answers to GROC. After we identify the key features, we separate them from the dataset and demonstrate the effectiveness of these features at identifying GROC. In doing so, we highlight possible directions for future study both mathematically and clinically.
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