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Register a new userA distillation based approach for the diagnosis of diseases
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Added by
Nibaran Das
Publication date
2021
fields
Informatics Engineering
and research's language is
English
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Presently, Covid-19 is a serious threat to the world at large. Efforts are being made to reduce disease screening times and in the development of a vaccine to resist this disease, even as thousands succumb to it everyday. We propose a novel method of automated screening of diseases like Covid-19 and pneumonia from Chest X-Ray images with the help of Computer Vision. Unlike computer vision classification algorithms which come with heavy computational costs, we propose a knowledge distillation based approach which allows us to bring down the model depth, while preserving the accuracy. We make use of an augmentation of the standard distillation module with an auxiliary intermediate assistant network that aids in the continuity of the flow of information. Following this approach, we are able to build an extremely light student network, consisting of just 3 convolutional blocks without any compromise on accuracy. We thus propose a method of classification of diseases which can not only lead to faster screening, but can also operate seamlessly on low-end devices.
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Over the last few decades, Lung Ultrasound (LUS) has been increasingly used to diagnose and monitor different lung diseases in neonates. It is a non invasive tool that allows a fast bedside examination while minimally handling the neonate. Acquiring a LUS scan is easy, but understanding the artifacts concerned with each respiratory disease is challenging. Mixed artifact patterns found in different respiratory diseases may limit LUS readability by the operator. While machine learning (ML), especially deep learning can assist in automated analysis, simply feeding the ultrasound images to an ML model for diagnosis is not enough to earn the trust of medical professionals. The algorithm should output LUS features that are familiar to the operator instead. Therefore, in this paper we present a unique approach for extracting seven meaningful LUS features that can be easily associated with a specific pathological lung condition: Normal pleura, irregular pleura, thick pleura, Alines, Coalescent B-lines, Separate B-lines and Consolidations. These artifacts can lead to early prediction of infants developing later respiratory distress symptoms. A single multi-class region proposal-based object detection model faster-RCNN (fRCNN) was trained on lower posterior lung ultrasound videos to detect these LUS features which are further linked to four common neonatal diseases. Our results show that fRCNN surpasses single stage models such as RetinaNet and can successfully detect the aforementioned LUS features with a mean average precision of 86.4%. Instead of a fully automatic diagnosis from images without any interpretability, detection of such LUS features leave the ultimate control of diagnosis to the clinician, which can result in a more trustworthy intelligent system.
In the real world, medical datasets often exhibit a long-tailed data distribution (i.e., a few classes occupy most of the data, while most classes have rarely few samples), which results in a challenging imbalance learning scenario. For example, there are estimated more than 40 different kinds of retinal diseases with variable morbidity, however with more than 30+ conditions are very rare from the global patient cohorts, which results in a typical long-tailed learning problem for deep learning-based screening models. In this study, we propose class subset learning by dividing the long-tailed data into multiple class subsets according to prior knowledge, such as regions and phenotype information. It enforces the model to focus on learning the subset-specific knowledge. More specifically, there are some relational classes that reside in the fixed retinal regions, or some common pathological features are observed in both the majority and minority conditions. With those subsets learnt teacher models, then we are able to distill the multiple teacher models into a unified model with weighted knowledge distillation loss. The proposed framework proved to be effective for the long-tailed retinal diseases recognition task. The experimental results on two different datasets demonstrate that our method is flexible and can be easily plugged into many other state-of-the-art techniques with significant improvements.
Skin conditions affect an estimated 1.9 billion people worldwide. A shortage of dermatologists causes long wait times and leads patients to seek dermatologic care from general practitioners. However, the diagnostic accuracy of general practitioners has been reported to be only 0.24-0.70 (compared to 0.77-0.96 for dermatologists), resulting in referral errors, delays in care, and errors in diagnosis and treatment. In this paper, we developed a deep learning system (DLS) to provide a differential diagnosis of skin conditions for clinical cases (skin photographs and associated medical histories). The DLS distinguishes between 26 skin conditions that represent roughly 80% of the volume of skin conditions seen in primary care. The DLS was developed and validated using de-identified cases from a teledermatology practice serving 17 clinical sites via a temporal split: the first 14,021 cases for development and the last 3,756 cases for validation. On the validation set, where a panel of three board-certified dermatologists defined the reference standard for every case, the DLS achieved 0.71 and 0.93 top-1 and top-3 accuracies respectively. For a random subset of the validation set (n=963 cases), 18 clinicians reviewed the cases for comparison. On this subset, the DLS achieved a 0.67 top-1 accuracy, non-inferior to board-certified dermatologists (0.63, p<0.001), and higher than primary care physicians (PCPs, 0.45) and nurse practitioners (NPs, 0.41). The top-3 accuracy showed a similar trend: 0.90 DLS, 0.75 dermatologists, 0.60 PCPs, and 0.55 NPs. These results highlight the potential of the DLS to augment general practitioners to accurately diagnose skin conditions by suggesting differential diagnoses that may not have been considered. Future work will be needed to prospectively assess the clinical impact of using this tool in actual clinical workflows.
Knee osteoarthritis (OA) is the most common musculoskeletal disorder. OA diagnosis is currently conducted by assessing symptoms and evaluating plain radiographs, but this process suffers from subjectivity. In this study, we present a new transparent computer-aided diagnosis method based on the Deep Siamese Convolutional Neural Network to automatically score knee OA severity according to the Kellgren-Lawrence grading scale. We trained our method using the data solely from the Multicenter Osteoarthritis Study and validated it on randomly selected 3,000 subjects (5,960 knees) from Osteoarthritis Initiative dataset. Our method yielded a quadratic Kappa coefficient of 0.83 and average multiclass accuracy of 66.71% compared to the annotations given by a committee of clinical experts. Here, we also report a radiological OA diagnosis area under the ROC curve of 0.93. We also present attention maps -- given as a class probability distribution -- highlighting the radiological features affecting the network decision. This information makes the decision process transparent for the practitioner, which builds better trust toward automatic methods. We believe that our model is useful for clinical decision making and for OA research; therefore, we openly release our training codes and the data set created in this study.
Breast cancer is one of the leading fatal disease worldwide with high risk control if early discovered. Conventional method for breast screening is x-ray mammography, which is known to be challenging for early detection of cancer lesions. The dense breast structure produced due to the compression process during imaging lead to difficulties to recognize small size abnormalities. Also, inter- and intra-variations of breast tissues lead to significant difficulties to achieve high diagnosis accuracy using hand-crafted features. Deep learning is an emerging machine learning technology that requires a relatively high computation power. Yet, it proved to be very effective in several difficult tasks that requires decision making at the level of human intelligence. In this paper, we develop a new network architecture inspired by the U-net structure that can be used for effective and early detection of breast cancer. Results indicate a high rate of sensitivity and specificity that indicate potential usefulness of the proposed approach in clinical use.
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