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Register a new userAn Empirical Framework for Domain Generalization in Clinical Settings
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Added by
Haoran Zhang
Publication date
2021
fields
Informatics Engineering
and research's language is
English
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Clinical machine learning models experience significantly degraded performance in datasets not seen during training, e.g., new hospitals or populations. Recent developments in domain generalization offer a promising solution to this problem by creating models that learn invariances across environments. In this work, we benchmark the performance of eight domain generalization methods on multi-site clinical time series and medical imaging data. We introduce a framework to induce synthetic but realistic domain shifts and sampling bias to stress-test these methods over existing non-healthcare benchmarks. We find that current domain generalization methods do not consistently achieve significant gains in out-of-distribution performance over empirical risk minimization on real-world medical imaging data, in line with prior work on general imaging datasets. However, a subset of realistic induced-shift scenarios in clinical time series data do exhibit limited performance gains. We characterize these scenarios in detail, and recommend best practices for domain generalization in the clinical setting.
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Modern deep neural networks suffer from performance degradation when evaluated on testing data under different distributions from training data. Domain generalization aims at tackling this problem by learning transferable knowledge from multiple source domains in order to generalize to unseen target domains. This paper introduces a novel Fourier-based perspective for domain generalization. The main assumption is that the Fourier phase information contains high-level semantics and is not easily affected by domain shifts. To force the model to capture phase information, we develop a novel Fourier-based data augmentation strategy called amplitude mix which linearly interpolates between the amplitude spectrums of two images. A dual-formed consistency loss called co-teacher regularization is further introduced between the predictions induced from original and augmented images. Extensive experiments on three benchmarks have demonstrated that the proposed method is able to achieve state-of-the-arts performance for domain generalization.
Machine learning systems typically assume that the distributions of training and test sets match closely. However, a critical requirement of such systems in the real world is their ability to generalize to unseen domains. Here, we propose an inter-domain gradient matching objective that targets domain generalization by maximizing the inner product between gradients from different domains. Since direct optimization of the gradient inner product can be computationally prohibitive -- requires computation of second-order derivatives -- we derive a simpler first-order algorithm named Fish that approximates its optimization. We demonstrate the efficacy of Fish on 6 datasets from the Wilds benchmark, which captures distribution shift across a diverse range of modalities. Our method produces competitive results on these datasets and surpasses all baselines on 4 of them. We perform experiments on both the Wilds benchmark, which captures distribution shift in the real world, as well as datasets in DomainBed benchmark that focuses more on synthetic-to-real transfer. Our method produces competitive results on both benchmarks, demonstrating its effectiveness across a wide range of domain generalization tasks.
The main challenge for domain generalization (DG) is to overcome the potential distributional shift between multiple training domains and unseen test domains. One popular class of DG algorithms aims to learn representations that have an invariant causal relation across the training domains. However, certain features, called emph{pseudo-invariant features}, may be invariant in the training domain but not the test domain and can substantially decreases the performance of existing algorithms. To address this issue, we propose a novel algorithm, called Invariant Information Bottleneck (IIB), that learns a minimally sufficient representation that is invariant across training and testing domains. By minimizing the mutual information between the representation and inputs, IIB alleviates its reliance on pseudo-invariant features, which is desirable for DG. To verify the effectiveness of the IIB principle, we conduct extensive experiments on large-scale DG benchmarks. The results show that IIB outperforms invariant learning baseline (e.g. IRM) by an average of 2.8% and 3.8% accuracy over two evaluation metrics.
Applications of machine learning (ML) to high-stakes policy settings -- such as education, criminal justice, healthcare, and social service delivery -- have grown rapidly in recent years, sparking important conversations about how to ensure fair outcomes from these systems. The machine learning research community has responded to this challenge with a wide array of proposed fairness-enhancing strategies for ML models, but despite the large number of methods that have been developed, little empirical work exists evaluating these methods in real-world settings. Here, we seek to fill this research gap by investigating the performance of several methods that operate at different points in the ML pipeline across four real-world public policy and social good problems. Across these problems, we find a wide degree of variability and inconsistency in the ability of many of these methods to improve model fairness, but post-processing by choosing group-specific score thresholds consistently removes disparities, with important implications for both the ML research community and practitioners deploying machine learning to inform consequential policy decisions.
Generalization to out-of-distribution (OOD) data is a capability natural to humans yet challenging for machines to reproduce. This is because most learning algorithms strongly rely on the i.i.d.~assumption on source/target data, which is often violated in practice due to domain shift. Domain generalization (DG) aims to achieve OOD generalization by using only source data for model learning. Since first introduced in 2011, research in DG has made great progresses. In particular, intensive research in this topic has led to a broad spectrum of methodologies, e.g., those based on domain alignment, meta-learning, data augmentation, or ensemble learning, just to name a few; and has covered various vision applications such as object recognition, segmentation, action recognition, and person re-identification. In this paper, for the first time a comprehensive literature review is provided to summarize the developments in DG for computer vision over the past decade. Specifically, we first cover the background by formally defining DG and relating it to other research fields like domain adaptation and transfer learning. Second, we conduct a thorough review into existing methods and present a categorization based on their methodologies and motivations. Finally, we conclude this survey with insights and discussions on future research directions.
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