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Register a new userHomogenization Theory of Ion Transportation in Multicellular Tissue
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Ion transport in biological tissues is crucial in the study of many biological and pathological problems. Some multi-cellular structures, like smooth muscles on the vessel walls, could be treated as periodic bi-domain structures, which consist of intracellular space and extracellular space with semipermeable membranes in between. With the aid of two-scale homogenization theory, macro-scale models are proposed based on an electro-neutral (EN) microscale model with nonlinear interface conditions, where membranes are treated as combinations of capacitors and resistors. The connectivity of intracellular space is also taken into consideration. If the intracellular space is fully connected and forms a syncytium, then the macroscale model is a bidomain nonlinear coupled partial differential equations system. Otherwise, when the intracellular cells are not connected, the macroscale model for intracellular space is an ordinary differential system with source/sink terms from the connected extracellular space.
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Let $(Omega, mu)$ be a probability space endowed with an ergodic action, $tau$ of $( {mathbb R} ^n, +)$. Let $H(x,p; omega)=H_omega(x,p)$ be a smooth Hamiltonian on $T^* {mathbb R} ^n$ parametrized by $omegain Omega$ and such that $ H(a+x,p;tau_aomega)=H(x,p;omega)$. We consider for an initial condition $fin C^0 ( {mathbb R}^n)$, the family of variational solutions of the stochastic Hamilton-Jacobi equations $$left{ begin{aligned} frac{partial u^{ varepsilon }}{partial t}(t,x;omega)+Hleft (frac{x}{ varepsilon } , frac{partial u^varepsilon }{partial x}(t,x;omega);omega right )=0 & u^varepsilon (0,x;omega)=f(x)& end{aligned} right .$$ Under some coercivity assumptions on $p$ -- but without any convexity assumption -- we prove that for a.e. $omega in Omega$ we have $C^0-lim u^{varepsilon}(t,x;omega)=v(t,x)$ where $v$ is the variational solution of the homogenized equation $$left{ begin{aligned} frac{partial v}{partial t}(x)+{overline H}left (frac{partial v }{partial x}(x) right )=0 & v (0,x)=f(x)& end{aligned} right.$$
This paper intents to present the state of art and recent developments of the optimal transportation theory with many marginals for a class of repulsive cost functions. We introduce some aspects of the Density Functional Theory (DFT) from a mathematical point of view, and revisit the theory of optimal transport from its perspective. Moreover, in the last three sections, we describe some recent and new theoretical and numerical results obtained for the Coulomb cost, the repulsive harmonic cost and the determinant cost.
This work develops a quantitative homogenization theory for random suspensions of rigid particles in a steady Stokes flow, and completes recent qualitative results. More precisely, we establish a large-scale regularity theory for this Stokes problem, and we prove moment bounds for the associated correctors and optimal estimates on the homogenization error; the latter further requires a quantitative ergodicity assumption on the random suspension. Compared to the corresponding quantitative homogenization theory for divergence-form linear elliptic equations, substantial difficulties arise from the analysis of the fluid incompressibility and the particle rigidity constraints. Our analysis further applies to the problem of stiff inclusions in (compressible or incompressible) linear elasticity and in electrostatics; it is also new in those cases, even in the periodic setting.
We consider a system of two kinetic equations modelling a multicellular system : The first equation governs the dynamics of cells, whereas the second kinetic equation governs the dynamics of the chemoattractant. For this system, we first prove the existence of global-in-time solution. The proof of existence relies on a fixed point procedure after establishing some a priori estimates. Then, we investigate the hyperbolic limit after rescaling of the kinetic system. It leads to a macroscopic system of Cattaneo type. The rigorous derivation is established thanks to a compactness method.
The multiphase Whitham modulation equations with $N$ phases have $2N$ characteristics which may be of hyperbolic or elliptic type. In this paper a nonlinear theory is developed for coalescence, where two characteristics change from hyperbolic to elliptic via collision. Firstly, a linear theory develops the structure of colliding characteristics involving the topological sign of characteristics and multiple Jordan chains, and secondly a nonlinear modulation theory is developed for transitions. The nonlinear theory shows that coalescing characteristics morph the Whitham equations into an asymptotically valid geometric form of the two-way Boussinesq equation. That is, coalescing characteristics generate dispersion, nonlinearity and complex wave fields. For illustration, the theory is applied to coalescing characteristics associated with the modulation of two-phase travelling-wave solutions of coupled nonlinear Schrodinger equations, highlighting how collisions can be identified and the relevant dispersive dynamics constructed.
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