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Register a new userOn the Hilbert Method in the Kinetic Theory of Multicellular Systems: Hyperbolic Limits and Convergence Proof
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Mohamed Khaladi
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We consider a system of two kinetic equations modelling a multicellular system : The first equation governs the dynamics of cells, whereas the second kinetic equation governs the dynamics of the chemoattractant. For this system, we first prove the existence of global-in-time solution. The proof of existence relies on a fixed point procedure after establishing some a priori estimates. Then, we investigate the hyperbolic limit after rescaling of the kinetic system. It leads to a macroscopic system of Cattaneo type. The rigorous derivation is established thanks to a compactness method.
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Ion transport in biological tissues is crucial in the study of many biological and pathological problems. Some multi-cellular structures, like smooth muscles on the vessel walls, could be treated as periodic bi-domain structures, which consist of intracellular space and extracellular space with semipermeable membranes in between. With the aid of two-scale homogenization theory, macro-scale models are proposed based on an electro-neutral (EN) microscale model with nonlinear interface conditions, where membranes are treated as combinations of capacitors and resistors. The connectivity of intracellular space is also taken into consideration. If the intracellular space is fully connected and forms a syncytium, then the macroscale model is a bidomain nonlinear coupled partial differential equations system. Otherwise, when the intracellular cells are not connected, the macroscale model for intracellular space is an ordinary differential system with source/sink terms from the connected extracellular space.
In this paper, we first prove that the cubic, defocusing nonlinear Schrodinger equation on the two dimensional hyperbolic space with radial initial data in $H^s(mathbb{H}^2)$ is globally well-posed and scatters when $s > frac{3}{4}$. Then we extend the result to nonlineraities of order $p>3$. The result is proved by extending the high-low method of Bourgain in the hyperbolic setting and by using a Morawetz type estimate proved by the first author and Ionescu.
We develop a version of Haar and Holmgren methods which applies to discontinuous solutions of nonlinear hyperbolic systems and allows us to control the L1 distance between two entropy solutions. The main difficulty is to cope with linear hyperbolic systems with discontinuous coefficients. Our main observation is that, while entropy solutions contain compressive shocks only, the averaged matrix associated with two such solutions has compressive or undercompressive shocks, but no rarefaction-shocks -- which are recognized as a source for non-uniqueness and instability. Our Haar-Holmgren-type method rests on the geometry associated with the averaged matrix and takes into account adjoint problems and wave cancellations along generalized characteristics. It extends the method proposed earlier by LeFloch et al. for genuinely nonlinear systems. In the present paper, we cover solutions with small total variation and a class of systems with general flux that need not be genuinely nonlinear and includes for instance fluid dynamics equations. We prove that solutions generated by Glimm or front tracking schemes depend continuously in the L1 norm upon their initial data, by exhibiting an L1 functional controling the distance between two solutions.
The present paper is devoted to finding a necessary and sufficient condition on the occurence of scattering for the regularly hyperbolic systems with time-dependent coefficients whose time-derivatives are integrable over the real line. More precisely, it will be shown that the solutions are asymptotically free if the coefficients are stable in the sense of the Riemann integrability as time goes to infinity, while each nontrivial solution is never asymptotically free provided that the coefficients are not R-stable as times goes to infinity. As a by-product, the scattering operator can be constructed. It is expected that the results obtained in the present paper would be brought into the study of the asymptotic behaviour of Kirchhoff systems.
Moment expansions are used as model reduction technique in kinetic gas theory to approximate the Boltzmann equation. Rarefied gas models based on so-called moment equations became increasingly popular recently. However, in a seminal paper by Holway [Phys. Fluids 7/6, (1965)] a fundamental restriction on the existence of the expansion was used to explain sub-shock behavior of shock profile solutions obtained by moment equations. Later, Weiss [Phys. Fluids 8/6, (1996)] argued that this restriction does not exist. We will revisit and discuss their findings and explain that both arguments have a correct and incorrect part. While a general convergence restriction for moment expansions does exist, it cannot be attributed to sub-shock solutions. We will also discuss the implications of the restriction and give some numerical evidence for our considerations.
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