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Assessing and managing the impact of large-scale epidemics considering only the individual risk and severity of the disease is exceedingly difficult and could be extremely expensive. Economic consequences, infrastructure and service disruption, as well as the recovery speed, are just a few of the many dimensions along which to quantify the effect of an epidemic on societys fabric. Here, we extend the concept of resilience to characterize epidemics in structured populations, by defining the system-wide critical functionality that combines an individuals risk of getting the disease (disease attack rate) and the disruption to the systems functionality (human mobility deterioration). By studying both conceptual and data-driven models, we show that the integrated consideration of individual risks and societal disruptions under resilience assessment framework provides an insightful picture of how an epidemic might impact society. In particular, containment interventions intended for a straightforward reduction of the risk may have net negative impact on the system by slowing down the recovery of basic societal functions. The presented study operationalizes the resilience framework, providing a more nuanced and comprehensive approach for optimizing containment schemes and mitigation policies in the case of epidemic outbreaks.
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We study the effect of the connectivity pattern of complex networks on the propagation dynamics of epidemics. The growth time scale of outbreaks is inversely proportional to the network degree fluctuations, signaling that epidemics spread almost instantaneously in networks with scale-free degree distributions. This feature is associated with an epidemic propagation that follows a precise hierarchical dynamics. Once the highly connected hubs are reached, the infection pervades the network in a progressive cascade across smaller degree classes. The present results are relevant for the development of adaptive containment strategies.
We introduce a version of the Minority Game where the total number of available choices is $D>2$, but the agents only have two available choices to switch. For all agents at an instant in any given choice, therefore, the other choice is distributed between the remaining $D-1$ options. This brings in the added complexity in reaching a state with the maximum resource utilization, in the sense that the game is essentially a set of MG that are coupled and played in parallel. We show that a stochastic strategy, used in the MG, works well here too. We discuss the limits in which the model reduces to other known models. Finally, we study an application of the model in the context of population movement between various states within a country during an ongoing epidemic. We show that the total infected population in the country could be as low as that achieved with a complete stoppage of inter-region movements for a prolonged period, provided that the agents instead follow the above mentioned stochastic strategy for their movement decisions between their two choices. The objective for an agent is to stay in the lower infected state between their two choices. We further show that it is the agents moving once between any two states, following the stochastic strategy, who are less likely to be infected than those not having (or not opting for) such a movement choice, when the risk of getting infected during the travel is not considered. This shows the incentive for the moving agents to follow the stochastic strategy.
We analyze the paper of Nathan D. Grubaugh et al. (Nature 546, 401-405, 2017) and find that it does not offer a convincing quantitative explanation for what generated the temporal distribution of human Zika virus (ZIKV) cases shown in their paper (Fig. 1d). We criticize this aspect because it is this understanding of how human cases develop from day-today and week-to-week within an area such as these Ground Zeros, that policymakers need in order to mitigate future outbreaks. We present results that strongly suggest that the missing piece is everyday human visit-revisit behavior. These results reproduce the human outbreak data in the key areas of Miami in 2016 very well, and give policymakers specific predictions for how changes in human flow through these areas will affect, and hence can be used to mitigate, future ZIka outbreaks in Miami and beyond.
Epidemic spreading has been studied for a long time and most of them are focused on the growing aspect of a single epidemic outbreak. Recently, we extended the study to the case of recurrent epidemics (Sci. Rep. {bf 5}, 16010 (2015)) but limited only to a single network. We here report from the real data of coupled regions or cities that the recurrent epidemics in two coupled networks are closely related to each other and can show either synchronized outbreak phase where outbreaks occur simultaneously in both networks or mixed outbreak phase where outbreaks occur in one network but do not in another one. To reveal the underlying mechanism, we present a two-layered network model of coupled recurrent epidemics to reproduce the synchronized and mixed outbreak phases. We show that the synchronized outbreak phase is preferred to be triggered in two coupled networks with the same average degree while the mixed outbreak phase is preferred for the case with different average degrees. Further, we show that the coupling between the two layers is preferred to suppress the mixed outbreak phase but enhance the synchronized outbreak phase. A theoretical analysis based on microscopic Markov-chain approach is presented to explain the numerical results. This finding opens a new window for studying the recurrent epidemics in multi-layered networks.
The COVID-19 pandemic poses challenges for continuing economic activity while reducing health risks. While these challenges can be mitigated through testing, testing budget is often limited. Here we study how institutions, such as nursing homes, should utilize a fixed test budget for early detection of an outbreak. Using an extended network-SEIR model, we show that given a certain budget of tests, it is generally better to test smaller subgroups of the population frequently than to test larger groups but less frequently. The numerical results are consistent with an analytical expression we derive for the size of the outbreak at detection in an exponential spread model. Our work provides a simple guideline for institutions: distribute your total tests over several batches instead of using them all at once. We expect that in the appropriate scenarios, this easy-to-implement policy recommendation will lead to earlier detection and better mitigation of local COVID-19 outbreaks.
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