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Register a new userOptical hyperpolarization and NMR detection of $^{129}$Xe on a microfluidic chip
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Added by
Ricardo Jimenez Martinez
Publication date
2013
fields
Physics
and research's language is
English
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Optically hyperpolarized $^{129}$Xe gas has become a powerful contrast agent in nuclear magnetic resonance (NMR) spectroscopy and imaging, with applications ranging from studies of the human lung to the targeted detection of biomolecules. Equally attractive is its potential use to enhance the sensitivity of microfluidic NMR experiments, in which small sample volumes yield poor sensitivity. Unfortunately, most $^{129}$Xe polarization systems are large and non-portable. Here we present a microfabricated chip that optically polarizes $^{129}$Xe gas. We have achieved $^{129}$Xe polarizations greater than 0.5$%$ at flow rates of several microliters per second, compatible with typical microfluidic applications. We employ in situ optical magnetometry to sensitively detect and characterize the $^{129}$Xe polarization at magnetic fields of 1 $mu$T. We construct the device using standard microfabrication techniques, which will facilitate its integration with existing microfluidic platforms. This device may enable the implementation of highly sensitive $^{129}$Xe NMR in compact, low-cost, portable devices.
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The optical properties of LXe in the vacuum ultra violet (VUV), determining the performance of a scintillation calorimeter, are discussed in detail. The available data, measured in a wider spectral region from visible to UV light, and in a large range of Xe densities, from gas to liquid, are examined. It is shown that this information can be used for deriving the LXe optical properties in the VUV. A comparison is made with the few direct measurements in LXe for VUV light resulting from the LXe excitation by ionizing particles. A useful relation is obtained which connects the Rayleigh scattering length to the refractive index in LXe.
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