Do you want to publish a course? Click here

Modelling the effects of air pollution on health using Bayesian Dynamic Generalised Linear Models

284   0   0.0 ( 0 )
 Added by Gavin Shaddick
 Publication date 2012
and research's language is English




Ask ChatGPT about the research

The relationship between short-term exposure to air pollution and mortality or morbidity has been the subject of much recent research, in which the standard method of analysis uses Poisson linear or additive models. In this paper we use a Bayesian dynamic generalised linear model (DGLM) to estimate this relationship, which allows the standard linear or additive model to be extended in two ways: (i) the long-term trend and temporal correlation present in the health data can be modelled by an autoregressive process rather than a smooth function of calendar time; (ii) the effects of air pollution are allowed to evolve over time. The efficacy of these two extensions are investigated by applying a series of dynamic and non-dynamic models to air pollution and mortality data from Greater London. A Bayesian approach is taken throughout, and a Markov chain monte carlo simulation algorithm is presented for inference. An alternative likelihood based analysis is also presented, in order to allow a direct comparison with the only previous analysis of air pollution and health data using a DGLM.



rate research

Read More

One of the most significant barriers to medication treatment is patients non-adherence to a prescribed medication regimen. The extent of the impact of poor adherence on resulting health measures is often unknown, and typical analyses ignore the time-varying nature of adherence. This paper develops a modeling framework for longitudinally recorded health measures modeled as a function of time-varying medication adherence or other time-varying covariates. Our framework, which relies on normal Bayesian dynamic linear models (DLMs), accounts for time-varying covariates such as adherence and non-dynamic covariates such as baseline health characteristics. Given the inefficiencies using standard inferential procedures for DLMs associated with infrequent and irregularly recorded response data, we develop an approach that relies on factoring the posterior density into a product of two terms; a marginal posterior density for the non-dynamic parameters, and a multivariate normal posterior density of the dynamic parameters conditional on the non-dynamic ones. This factorization leads to a two-stage process for inference in which the non-dynamic parameters can be inferred separately from the time-varying parameters. We demonstrate the application of this model to the time-varying effect of anti-hypertensive medication on blood pressure levels from a cohort of patients diagnosed with hypertension. Our model results are compared to ones in which adherence is incorporated through non-dynamic summaries.
Forecasts of mortality provide vital information about future populations, with implications for pension and health-care policy as well as for decisions made by private companies about life insurance and annuity pricing. Stochastic mortality forecasts allow the uncertainty in mortality predictions to be taken into consideration when making policy decisions and setting product prices. Longer lifespans imply that forecasts of mortality at ages 90 and above will become more important in such calculations. This paper presents a Bayesian approach to the forecasting of mortality that jointly estimates a Generalised Additive Model (GAM) for mortality for the majority of the age-range and a parametric model for older ages where the data are sparser. The GAM allows smooth components to be estimated for age, cohort and age-specific improvement rates, together with a non-smoothed period effect. Forecasts for the United Kingdom are produced using data from the Human Mortality Database spanning the period 1961-2013. A metric that approximates predictive accuracy under Leave-One-Out cross-validation is used to estimate weights for the `stacking of forecasts with different points of transition between the GAM and parametric elements. Mortality for males and females are estimated separately at first, but a joint model allows the asymptotic limit of mortality at old ages to be shared between sexes, and furthermore provides for forecasts accounting for correlations in period innovations. The joint and single sex model forecasts estimated using data from 1961-2003 are compared against observed data from 2004-2013 to facilitate model assessment.
Air pollution constitutes the highest environmental risk factor in relation to heath. In order to provide the evidence required for health impact analyses, to inform policy and to develop potential mitigation strategies comprehensive information is required on the state of air pollution. Information on air pollution traditionally comes from ground monitoring (GM) networks but these may not be able to provide sufficient coverage and may need to be supplemented with information from other sources (e.g. chemical transport models; CTMs). However, these may only be available on grids and may not capture micro-scale features that may be important in assessing air quality in areas of high population. We develop a model that allows calibration between multiple data sources available at different levels of support by allowing the coefficients of calibration equations to vary over space and time, enabling downscaling where the data is sufficient to support it. The model is used to produce high-resolution (1km $times$ 1km) estimates of NO$_2$ and PM$_{2.5}$ across Western Europe for 2010-2016. Concentrations of both pollutants are decreasing during this period, however there remain large populations exposed to levels exceeding the WHO Air Quality Guidelines and thus air pollution remains a serious threat to health.
Estimation of the long-term health effects of air pollution is a challenging task, especially when modelling small-area disease incidence data in an ecological study design. The challenge comes from the unobserved underlying spatial correlation structure in these data, which is accounted for using random effects modelled by a globally smooth conditional autoregressive model. These smooth random effects confound the effects of air pollution, which are also globally smooth. To avoid this collinearity a Bayesian localised conditional autoregressive model is developed for the random effects. This localised model is flexible spatially, in the sense that it is not only able to model step changes in the random effects surface, but also is able to capture areas of spatial smoothness in the study region. This methodological development allows us to improve the estimation performance of the covariate effects, compared to using traditional conditional auto-regressive models. These results are established using a simulation study, and are then illustrated with our motivating study on air pollution and respiratory ill health in Greater Glasgow, Scotland in 2010. The model shows substantial health effects of particulate matter air pollution and income deprivation, whose effects have been consistently attenuated by the currently available globally smooth models.
We propose a versatile joint regression framework for count responses. The method is implemented in the R add-on package GJRM and allows for modelling linear and non-linear dependence through the use of several copulae. Moreover, the parameters of the marginal distributions of the count responses and of the copula can be specified as flexible functions of covariates. Motivated by a football application, we also discuss an extension which forces the regression coefficients of the marginal (linear) predictors to be equal via a suitable penalisation. Model fitting is based on a trust region algorithm which estimates simultaneously all the parameters of the joint models. We investigate the proposals empirical performance in two simulation studies, the first one designed for arbitrary count data, the other one reflecting football-specific settings. Finally, the method is applied to FIFA World Cup data, showing its competitiveness to the standard approach with regard to predictive performance.
comments
Fetching comments Fetching comments
Sign in to be able to follow your search criteria
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا