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Register a new userDomain Adaptive Cascade R-CNN for MItosis DOmain Generalization (MIDOG) Challenge
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We present a summary of the domain adaptive cascade R-CNN method for mitosis detection of digital histopathology images. By comprehensive data augmentation and adapting existing popular detection architecture, our proposed method has achieved an F1 score of 0.7500 on the preliminary test set in MItosis DOmain Generalization (MIDOG) Challenge at MICCAI2021.
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The domain gap caused mainly by variable medical image quality renders a major obstacle on the path between training a segmentation model in the lab and applying the trained model to unseen clinical data. To address this issue, domain generalization methods have been proposed, which however usually use static convolutions and are less flexible. In this paper, we propose a multi-source domain generalization model, namely domain and content adaptive convolution (DCAC), for medical image segmentation. Specifically, we design the domain adaptive convolution (DAC) module and content adaptive convolution (CAC) module and incorporate both into an encoder-decoder backbone. In the DAC module, a dynamic convolutional head is conditioned on the predicted domain code of the input to make our model adapt to the unseen target domain. In the CAC module, a dynamic convolutional head is conditioned on the global image features to make our model adapt to the test image. We evaluated the DCAC model against the baseline and four state-of-the-art domain generalization methods on the prostate segmentation, COVID-19 lesion segmentation, and optic cup/optic disc segmentation tasks. Our results indicate that the proposed DCAC model outperforms all competing methods on each segmentation task, and also demonstrate the effectiveness of the DAC and CAC modules.
Mitotic count is the most important morphological feature of breast cancer grading. Many deep learning-based methods have been proposed but suffer from domain shift. In this work, we construct a Fourier-based segmentation model for mitosis detection to address the problem. Swapping the low-frequency spectrum of source and target images is shown effective to alleviate the discrepancy between different scanners. Our Fourier-based segmentation method can achieve F1 with 0.7456 on the preliminary test set.
Mitotic figure count is an important marker of tumor proliferation and has been shown to be associated with patients prognosis. Deep learning based mitotic figure detection methods have been utilized to automatically locate the cell in mitosis using hematoxylin & eosin (H&E) stained images. However, the model performance deteriorates due to the large variation of color tone and intensity in H&E images. In this work, we proposed a two stage mitotic figure detection framework by fusing a detector and a deep ensemble classification model. To alleviate the impact of color variation in H&E images, we utilize both stain normalization and data augmentation, aiding model to learn color irrelevant features. The proposed model obtains an F1 score of 0.7550 on the preliminary testing set released by the MIDOG challenge.
Left atrial (LA) segmentation from late gadolinium enhanced magnetic resonance imaging (LGE MRI) is a crucial step needed for planning the treatment of atrial fibrillation. However, automatic LA segmentation from LGE MRI is still challenging, due to the poor image quality, high variability in LA shapes, and unclear LA boundary. Though deep learning-based methods can provide promising LA segmentation results, they often generalize poorly to unseen domains, such as data from different scanners and/or sites. In this work, we collect 210 LGE MRIs from different centers with different levels of image quality. To evaluate the domain generalization ability of models on the LA segmentation task, we employ four commonly used semantic segmentation networks for the LA segmentation from multi-center LGE MRIs. Besides, we investigate three domain generalization strategies, i.e., histogram matching, mutual information based disentangled representation, and random style transfer, where a simple histogram matching is proved to be most effective.
Single domain generalization aims to learn a model that performs well on many unseen domains with only one domain data for training. Existing works focus on studying the adversarial domain augmentation (ADA) to improve the models generalization capability. The impact on domain generalization of the statistics of normalization layers is still underinvestigated. In this paper, we propose a generic normalization approach, adaptive standardization and rescaling normalization (ASR-Norm), to complement the missing part in previous works. ASR-Norm learns both the standardization and rescaling statistics via neural networks. This new form of normalization can be viewed as a generic form of the traditional normalizations. When trained with ADA, the statistics in ASR-Norm are learned to be adaptive to the data coming from different domains, and hence improves the model generalization performance across domains, especially on the target domain with large discrepancy from the source domain. The experimental results show that ASR-Norm can bring consistent improvement to the state-of-the-art ADA approaches by 1.6%, 2.7%, and 6.3% averagely on the Digits, CIFAR-10-C, and PACS benchmarks, respectively. As a generic tool, the improvement introduced by ASR-Norm is agnostic to the choice of ADA methods.
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