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Register a new userNeural Networks for Parameter Estimation in Intractable Models
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Added by
Amanda Lenzi
Publication date
2021
fields
Mathematical Statistics
and research's language is
English
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We propose to use deep learning to estimate parameters in statistical models when standard likelihood estimation methods are computationally infeasible. We show how to estimate parameters from max-stable processes, where inference is exceptionally challenging even with small datasets but simulation is straightforward. We use data from model simulations as input and train deep neural networks to learn statistical parameters. Our neural-network-based method provides a competitive alternative to current approaches, as demonstrated by considerable accuracy and computational time improvements. It serves as a proof of concept for deep learning in statistical parameter estimation and can be extended to other estimation problems.
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In a Gaussian graphical model, the conditional independence between two variables are characterized by the corresponding zero entries in the inverse covariance matrix. Maximum likelihood method using the smoothly clipped absolute deviation (SCAD) penalty (Fan and Li, 2001) and the adaptive LASSO penalty (Zou, 2006) have been proposed in literature. In this article, we establish the result that using Bayesian information criterion (BIC) to select the tuning parameter in penalized likelihood estimation with both types of penalties can lead to consistent graphical model selection. We compare the empirical performance of BIC with cross validation method and demonstrate the advantageous performance of BIC criterion for tuning parameter selection through simulation studies.
Models with intractable normalizing functions have numerous applications ranging from network models to image analysis to spatial point processes. Because the normalizing constants are functions of the parameters of interest, standard Markov chain Monte Carlo cannot be used for Bayesian inference for these models. A number of algorithms have been developed for such models. Some have the posterior distribution as the asymptotic distribution. Other asymptotically inexact algorithms do not possess this property. There is limited guidance for evaluating approximations based on these algorithms, and hence it is very hard to tune them. We propose two new diagnostics that address these problems for intractable normalizing function models. Our first diagnostic, inspired by the second Bartlett identity, applies in principle to any asymptotically exact or inexact algorithm. We develop an approximate version of this new diagnostic that is applicable to intractable normalizing function problems. Our second diagnostic is a Monte Carlo approximation to a kernel Stein discrepancy-based diagnostic introduced by Gorham and Mackey (2017). We provide theoretical justification for our methods. We apply our diagnostics to several algorithms in the context of challenging simulated and real data examples, including an Ising model, an exponential random graph model, and a Markov point process.
Parameters in deep neural networks which are trained on large-scale databases can generalize across multiple domains, which is referred as transferability. Unfortunately, the transferability is usually defined as discrete states and it differs with domains and network architectures. Existing works usually heuristically apply parameter-sharing or fine-tuning, and there is no principled approach to learn a parameter transfer strategy. To address the gap, a parameter transfer unit (PTU) is proposed in this paper. The PTU learns a fine-grained nonlinear combination of activations from both the source and the target domain networks, and subsumes hand-crafted discrete transfer states. In the PTU, the transferability is controlled by two gates which are artificial neurons and can be learned from data. The PTU is a general and flexible module which can be used in both CNNs and RNNs. Experiments are conducted with various network architectures and multiple transfer domain pairs. Results demonstrate the effectiveness of the PTU as it outperforms heuristic parameter-sharing and fine-tuning in most settings.
The estimation of causal effects is a primary goal of behavioral, social, economic and biomedical sciences. Under the unconfounded treatment assignment condition, adjustment for confounders requires estimating the nuisance functions relating outcome and/or treatment to confounders. The conventional approaches rely on either a parametric or a nonparametric modeling strategy to approximate the nuisance functions. Parametric methods can introduce serious bias into casual effect estimation due to possible mis-specification, while nonparametric estimation suffers from the curse of dimensionality. This paper proposes a new unified approach for efficient estimation of treatment effects using feedforward artificial neural networks when the number of covariates is allowed to increase with the sample size. We consider a general optimization framework that includes the average, quantile and asymmetric least squares treatment effects as special cases. Under this unified setup, we develop a generalized optimization estimator for the treatment effect with the nuisance function estimated by neural networks. We further establish the consistency and asymptotic normality of the proposed estimator and show that it attains the semiparametric efficiency bound. The proposed methods are illustrated via simulation studies and a real data application.
Boolean networks have long been used as models of molecular networks and play an increasingly important role in systems biology. This paper describes a software package, Polynome, offered as a web service, that helps users construct Boolean network models based on experimental data and biological input. The key feature is a discrete analog of parameter estimation for continuous models. With only experimental data as input, the software can be used as a tool for reverse-engineering of Boolean network models from experimental time course data.
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