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Register a new userBEFD: Boundary Enhancement and Feature Denoising for Vessel Segmentation
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Blood vessel segmentation is crucial for many diagnostic and research applications. In recent years, CNN-based models have leaded to breakthroughs in the task of segmentation, however, such methods usually lose high-frequency information like object boundaries and subtle structures, which are vital to vessel segmentation. To tackle this issue, we propose Boundary Enhancement and Feature Denoising (BEFD) module to facilitate the network ability of extracting boundary information in semantic segmentation, which can be integrated into arbitrary encoder-decoder architecture in an end-to-end way. By introducing Sobel edge detector, the network is able to acquire additional edge prior, thus enhancing boundary in an unsupervised manner for medical image segmentation. In addition, we also utilize a denoising block to reduce the noise hidden in the low-level features. Experimental results on retinal vessel dataset and angiocarpy dataset demonstrate the superior performance of the new BEFD module.
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Retinal blood vessel can assist doctors in diagnosis of eye-related diseases such as diabetes and hypertension, and its segmentation is particularly important for automatic retinal image analysis. However, it is challenging to segment these vessels structures, especially the thin capillaries from the color retinal image due to low contrast and ambiguousness. In this paper, we propose pyramid U-Net for accurate retinal vessel segmentation. In pyramid U-Net, the proposed pyramid-scale aggregation blocks (PSABs) are employed in both the encoder and decoder to aggregate features at higher, current and lower levels. In this way, coarse-to-fine context information is shared and aggregated in each block thus to improve the location of capillaries. To further improve performance, two optimizations including pyramid inputs enhancement and deep pyramid supervision are applied to PSABs in the encoder and decoder, respectively. For PSABs in the encoder, scaled input images are added as extra inputs. While for PSABs in the decoder, scaled intermediate outputs are supervised by the scaled segmentation labels. Extensive evaluations show that our pyramid U-Net outperforms the current state-of-the-art methods on the public DRIVE and CHASE-DB1 datasets.
Sturge-Weber syndrome (SWS) is a vascular malformation disease, and it may cause blindness if the patients condition is severe. Clinical results show that SWS can be divided into two types based on the characteristics of scleral blood vessels. Therefore, how to accurately segment scleral blood vessels has become a significant problem in computer-aided diagnosis. In this research, we propose to continuously upsample the bottom layers feature maps to preserve image details, and design a novel Claw UNet based on UNet for scleral blood vessel segmentation. Specifically, the residual structure is used to increase the number of network layers in the feature extraction stage to learn deeper features. In the decoding stage, by fusing the features of the encoding, upsampling, and decoding parts, Claw UNet can achieve effective segmentation in the fine-grained regions of scleral blood vessels. To effectively extract small blood vessels, we use the attention mechanism to calculate the attention coefficient of each position in images. Claw UNet outperforms other UNet-based networks on scleral blood vessel image dataset.
Vessel segmentation is an essential task in many clinical applications. Although supervised methods have achieved state-of-art performance, acquiring expert annotation is laborious and mostly limited for two-dimensional datasets with a small sample size. On the contrary, unsupervised methods rely on handcrafted features to detect tube-like structures such as vessels. However, those methods require complex pipelines involving several hyper-parameters and design choices rendering the procedure sensitive, dataset-specific, and not generalizable. We propose a self-supervised method with a limited number of hyper-parameters that is generalizable across modalities. Our method uses tube-like structure properties, such as connectivity, profile consistency, and bifurcation, to introduce inductive bias into a learning algorithm. To model those properties, we generate a vector field that we refer to as a flow. Our experiments on various public datasets in 2D and 3D show that our method performs better than unsupervised methods while learning useful transferable features from unlabeled data. Unlike generic self-supervised methods, the learned features learn vessel-relevant features that are transferable for supervised approaches, which is essential when the number of annotated data is limited.
Analyzing the morphological attributes of blood vessels plays a critical role in the computer-aided diagnosis of many cardiovascular and ophthalmologic diseases. Although being extensively studied, segmentation of blood vessels, particularly thin vessels and capillaries, remains challenging mainly due to the lack of an effective interaction between local and global features. In this paper, we propose a novel deep learning model called PC-Net to segment retinal vessels and major arteries in 2D fundus image and 3D computed tomography angiography (CTA) scans, respectively. In PC-Net, the pyramid squeeze-and-excitation (PSE) module introduces spatial information to each convolutional block, boosting its ability to extract more effective multi-scale features, and the coarse-to-fine (CF) module replaces the conventional decoder to enhance the details of thin vessels and process hard-to-classify pixels again. We evaluated our PC-Net on the Digital Retinal Images for Vessel Extraction (DRIVE) database and an in-house 3D major artery (3MA) database against several recent methods. Our results not only demonstrate the effectiveness of the proposed PSE module and CF module, but also suggest that our proposed PC-Net sets new state of the art in the segmentation of retinal vessels (AUC: 98.31%) and major arteries (AUC: 98.35%) on both databases, respectively.
The precise detection of blood vessels in retinal images is crucial to the early diagnosis of the retinal vascular diseases, e.g., diabetic, hypertensive and solar retinopathies. Existing works often fail in predicting the abnormal areas, e.g, sudden brighter and darker areas and are inclined to predict a pixel to background due to the significant class imbalance, leading to high accuracy and specificity while low sensitivity. To that end, we propose a novel error attention refining network (ERA-Net) that is capable of learning and predicting the potential false predictions in a two-stage manner for effective retinal vessel segmentation. The proposed ERA-Net in the refine stage drives the model to focus on and refine the segmentation errors produced in the initial training stage. To achieve this, unlike most previous attention approaches that run in an unsupervised manner, we introduce a novel error attention mechanism which considers the differences between the ground truth and the initial segmentation masks as the ground truth to supervise the attention map learning. Experimental results demonstrate that our method achieves state-of-the-art performance on two common retinal blood vessel datasets.
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