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Register a new userDeepGLEAM: A hybrid mechanistic and deep learning model for COVID-19 forecasting
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Added by
Liyao Gao
Publication date
2021
fields
Informatics Engineering
and research's language is
English
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We introduce DeepGLEAM, a hybrid model for COVID-19 forecasting. DeepGLEAM combines a mechanistic stochastic simulation model GLEAM with deep learning. It uses deep learning to learn the correction terms from GLEAM, which leads to improved performance. We further integrate various uncertainty quantification methods to generate confidence intervals. We demonstrate DeepGLEAM on real-world COVID-19 mortality forecasting tasks.
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The COVID-19 pandemic represents the most significant public health disaster since the 1918 influenza pandemic. During pandemics such as COVID-19, timely and reliable spatio-temporal forecasting of epidemic dynamics is crucial. Deep learning-based time series models for forecasting have recently gained popularity and have been successfully used for epidemic forecasting. Here we focus on the design and analysis of deep learning-based models for COVID-19 forecasting. We implement multiple recurrent neural network-based deep learning models and combine them using the stacking ensemble technique. In order to incorporate the effects of multiple factors in COVID-19 spread, we consider multiple sources such as COVID-19 confirmed and death case count data and testing data for better predictions. To overcome the sparsity of training data and to address the dynamic correlation of the disease, we propose clustering-based training for high-resolution forecasting. The methods help us to identify the similar trends of certain groups of regions due to various spatio-temporal effects. We examine the proposed method for forecasting weekly COVID-19 new confirmed cases at county-, state-, and country-level. A comprehensive comparison between different time series models in COVID-19 context is conducted and analyzed. The results show that simple deep learning models can achieve comparable or better performance when compared with more complicated models. We are currently integrating our methods as a part of our weekly forecasts that we provide state and federal authorities.
We have entered an era of a pandemic that has shaken the world with major impact to medical systems, economics and agriculture. Prominent computational and mathematical models have been unreliable due to the complexity of the spread of infections. Moreover, lack of data collection and reporting makes any such modelling attempts unreliable. Hence we need to re-look at the situation with the latest data sources and most comprehensive forecasting models. Deep learning models such as recurrent neural networks are well suited for modelling temporal sequences. In this paper, prominent recurrent neural networks, in particular textit{long short term memory} (LSTMs) networks, bidirectional LSTM, and encoder-decoder LSTM models for multi-step (short-term) forecasting the spread of COVID-infections among selected states in India. We select states with COVID-19 hotpots in terms of the rate of infections and compare with states where infections have been contained or reached their peak and provide two months ahead forecast that shows that cases will slowly decline. Our results show that long-term forecasts are promising which motivates the application of the method in other countries or areas. We note that although we made some progress in forecasting, the challenges in modelling remain due to data and difficulty in capturing factors such as population density, travel logistics, and social aspects such culture and lifestyle.
The COVID-19 pandemic has profound global consequences on health, economic, social, political, and almost every major aspect of human life. Therefore, it is of great importance to model COVID-19 and other pandemics in terms of the broader social contexts in which they take place. We present the architecture of AICov, which provides an integrative deep learning framework for COVID-19 forecasting with population covariates, some of which may serve as putative risk factors. We have integrated multiple different strategies into AICov, including the ability to use deep learning strategies based on LSTM and even modeling. To demonstrate our approach, we have conducted a pilot that integrates population covariates from multiple sources. Thus, AICov not only includes data on COVID-19 cases and deaths but, more importantly, the populations socioeconomic, health and behavioral risk factors at a local level. The compiled data are fed into AICov, and thus we obtain improved prediction by integration of the data to our model as compared to one that only uses case and death data.
We established a Spatio-Temporal Neural Network, namely STNN, to forecast the spread of the coronavirus COVID-19 outbreak worldwide in 2020. The basic structure of STNN is similar to the Recurrent Neural Network (RNN) incorporating with not only temporal data but also spatial features. Two improved STNN architectures, namely the STNN with Augmented Spatial States (STNN-A) and the STNN with Input Gate (STNN-I), are proposed, which ensure more predictability and flexibility. STNN and its variants can be trained using Stochastic Gradient Descent (SGD) algorithm and its improved variants (e.g., Adam, AdaGrad and RMSProp). Our STNN models are compared with several classical epidemic prediction models, including the fully-connected neural network (BPNN), and the recurrent neural network (RNN), the classical curve fitting models, as well as the SEIR dynamical system model. Numerical simulations demonstrate that STNN models outperform many others by providing more accurate fitting and prediction, and by handling both spatial and temporal data.
Forecasting influenza in a timely manner aids health organizations and policymakers in adequate preparation and decision making. However, effective influenza forecasting still remains a challenge despite increasing research interest. It is even more challenging amidst the COVID pandemic, when the influenza-like illness (ILI) counts are affected by various factors such as symptomatic similarities with COVID-19 and shift in healthcare seeking patterns of the general population. Under the current pandemic, historical influenza models carry valuable expertise about the disease dynamics but face difficulties adapting. Therefore, we propose CALI-Net, a neural transfer learning architecture which allows us to steer a historical disease forecasting model to new scenarios where flu and COVID co-exist. Our framework enables this adaptation by automatically learning when it should emphasize learning from COVID-related signals and when it should learn from the historical model. Thus, we exploit representations learned from historical ILI data as well as the limited COVID-related signals. Our experiments demonstrate that our approach is successful in adapting a historical forecasting model to the current pandemic. In addition, we show that success in our primary goal, adaptation, does not sacrifice overall performance as compared with state-of-the-art influenza forecasting approaches.
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