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Register a new userSelf-supervised Feature Learning via Exploiting Multi-modal Data for Retinal Disease Diagnosis
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Xiaomeng Li
Publication date
2020
fields
Informatics Engineering
and research's language is
English
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The automatic diagnosis of various retinal diseases from fundus images is important to support clinical decision-making. However, developing such automatic solutions is challenging due to the requirement of a large amount of human-annotated data. Recently, unsupervised/self-supervised feature learning techniques receive a lot of attention, as they do not need massive annotations. Most of the current self-supervised methods are analyzed with single imaging modality and there is no method currently utilize multi-modal images for better results. Considering that the diagnostics of various vitreoretinal diseases can greatly benefit from another imaging modality, e.g., FFA, this paper presents a novel self-supervised feature learning method by effectively exploiting multi-modal data for retinal disease diagnosis. To achieve this, we first synthesize the corresponding FFA modality and then formulate a patient feature-based softmax embedding objective. Our objective learns both modality-invariant features and patient-similarity features. Through this mechanism, the neural network captures the semantically shared information across different modalities and the apparent visual similarity between patients. We evaluate our method on two public benchmark datasets for retinal disease diagnosis. The experimental results demonstrate that our method clearly outperforms other self-supervised feature learning methods and is comparable to the supervised baseline.
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Most of the existing self-supervised feature learning methods for 3D data either learn 3D features from point cloud data or from multi-view images. By exploring the inherent multi-modality attributes of 3D objects, in this paper, we propose to jointly learn modal-invariant and view-invariant features from different modalities including image, point cloud, and mesh with heterogeneous networks for 3D data. In order to learn modal- and view-invariant features, we propose two types of constraints: cross-modal invariance constraint and cross-view invariant constraint. Cross-modal invariance constraint forces the network to maximum the agreement of features from different modalities for same objects, while the cross-view invariance constraint forces the network to maximum agreement of features from different views of images for same objects. The quality of learned features has been tested on different downstream tasks with three modalities of data including point cloud, multi-view images, and mesh. Furthermore, the invariance cross different modalities and views are evaluated with the cross-modal retrieval task. Extensive evaluation results demonstrate that the learned features are robust and have strong generalizability across different tasks.
The crux of self-supervised video representation learning is to build general features from unlabeled videos. However, most recent works have mainly focused on high-level semantics and neglected lower-level representations and their temporal relationship which are crucial for general video understanding. To address these challenges, this paper proposes a multi-level feature optimization framework to improve the generalization and temporal modeling ability of learned video representations. Concretely, high-level features obtained from naive and prototypical contrastive learning are utilized to build distribution graphs, guiding the process of low-level and mid-level feature learning. We also devise a simple temporal modeling module from multi-level features to enhance motion pattern learning. Experiments demonstrate that multi-level feature optimization with the graph constraint and temporal modeling can greatly improve the representation ability in video understanding. Code is available at https://github.com/shvdiwnkozbw/Video-Representation-via-Multi-level-Optimization.
Retinal lesions play a vital role in the accurate classification of retinal abnormalities. Many researchers have proposed deep lesion-aware screening systems that analyze and grade the progression of retinopathy. However, to the best of our knowledge, no literature exploits the tendency of these systems to generalize across multiple scanner specifications and multi-modal imagery. Towards this end, this paper presents a detailed evaluation of semantic segmentation, scene parsing and hybrid deep learning systems for extracting the retinal lesions such as intra-retinal fluid, sub-retinal fluid, hard exudates, drusen, and other chorioretinal anomalies from fused fundus and optical coherence tomography (OCT) imagery. Furthermore, we present a novel strategy exploiting the transferability of these models across multiple retinal scanner specifications. A total of 363 fundus and 173,915 OCT scans from seven publicly available datasets were used in this research (from which 297 fundus and 59,593 OCT scans were used for testing purposes). Overall, a hybrid retinal analysis and grading network (RAGNet), backboned through ResNet-50, stood first for extracting the retinal lesions, achieving a mean dice coefficient score of 0.822. Moreover, the complete source code and its documentation are released at: http://biomisa.org/index.php/downloads/.
Longitudinal imaging is capable of capturing the static ana-to-mi-cal structures and the dynamic changes of the morphology resulting from aging or disease progression. Self-supervised learning allows to learn new representation from available large unlabelled data without any expert knowledge. We propose a deep learning self-supervised approach to model disease progression from longitudinal retinal optical coherence tomography (OCT). Our self-supervised model takes benefit from a generic time-related task, by learning to estimate the time interval between pairs of scans acquired from the same patient. This task is (i) easy to implement, (ii) allows to use irregularly sampled data, (iii) is tolerant to poor registration, and (iv) does not rely on additional annotations. This novel method learns a representation that focuses on progression specific information only, which can be transferred to other types of longitudinal problems. We transfer the learnt representation to a clinically highly relevant task of predicting the onset of an advanced stage of age-related macular degeneration within a given time interval based on a single OCT scan. The boost in prediction accuracy, in comparison to a network learned from scratch or transferred from traditional tasks, demonstrates that our pretrained self-supervised representation learns a clinically meaningful information.
Surgical data science is a new research field that aims to observe all aspects of the patient treatment process in order to provide the right assistance at the right time. Due to the breakthrough successes of deep learning-based solutions for automatic image annotation, the availability of reference annotations for algorithm training is becoming a major bottleneck in the field. The purpose of this paper was to investigate the concept of self-supervised learning to address this issue. Our approach is guided by the hypothesis that unlabeled video data can be used to learn a representation of the target domain that boosts the performance of state-of-the-art machine learning algorithms when used for pre-training. Core of the method is an auxiliary task based on raw endoscopic video data of the target domain that is used to initialize the convolutional neural network (CNN) for the target task. In this paper, we propose the re-colorization of medical images with a generative adversarial network (GAN)-based architecture as auxiliary task. A variant of the method involves a second pre-training step based on labeled data for the target task from a related domain. We validate both variants using medical instrument segmentation as target task. The proposed approach can be used to radically reduce the manual annotation effort involved in training CNNs. Compared to the baseline approach of generating annotated data from scratch, our method decreases exploratively the number of labeled images by up to 75% without sacrificing performance. Our method also outperforms alternative methods for CNN pre-training, such as pre-training on publicly available non-medical or medical data using the target task (in this instance: segmentation). As it makes efficient use of available (non-)public and (un-)labeled data, the approach has the potential to become a valuable tool for CNN (pre-)training.
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