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Register a new userExploiting the Transferability of Deep Learning Systems Across Multi-modal Retinal Scans for Extracting Retinopathy Lesions
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Retinal lesions play a vital role in the accurate classification of retinal abnormalities. Many researchers have proposed deep lesion-aware screening systems that analyze and grade the progression of retinopathy. However, to the best of our knowledge, no literature exploits the tendency of these systems to generalize across multiple scanner specifications and multi-modal imagery. Towards this end, this paper presents a detailed evaluation of semantic segmentation, scene parsing and hybrid deep learning systems for extracting the retinal lesions such as intra-retinal fluid, sub-retinal fluid, hard exudates, drusen, and other chorioretinal anomalies from fused fundus and optical coherence tomography (OCT) imagery. Furthermore, we present a novel strategy exploiting the transferability of these models across multiple retinal scanner specifications. A total of 363 fundus and 173,915 OCT scans from seven publicly available datasets were used in this research (from which 297 fundus and 59,593 OCT scans were used for testing purposes). Overall, a hybrid retinal analysis and grading network (RAGNet), backboned through ResNet-50, stood first for extracting the retinal lesions, achieving a mean dice coefficient score of 0.822. Moreover, the complete source code and its documentation are released at: http://biomisa.org/index.php/downloads/.
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The automatic diagnosis of various retinal diseases from fundus images is important to support clinical decision-making. However, developing such automatic solutions is challenging due to the requirement of a large amount of human-annotated data. Recently, unsupervised/self-supervised feature learning techniques receive a lot of attention, as they do not need massive annotations. Most of the current self-supervised methods are analyzed with single imaging modality and there is no method currently utilize multi-modal images for better results. Considering that the diagnostics of various vitreoretinal diseases can greatly benefit from another imaging modality, e.g., FFA, this paper presents a novel self-supervised feature learning method by effectively exploiting multi-modal data for retinal disease diagnosis. To achieve this, we first synthesize the corresponding FFA modality and then formulate a patient feature-based softmax embedding objective. Our objective learns both modality-invariant features and patient-similarity features. Through this mechanism, the neural network captures the semantically shared information across different modalities and the apparent visual similarity between patients. We evaluate our method on two public benchmark datasets for retinal disease diagnosis. The experimental results demonstrate that our method clearly outperforms other self-supervised feature learning methods and is comparable to the supervised baseline.
Medical image captioning automatically generates a medical description to describe the content of a given medical image. A traditional medical image captioning model creates a medical description only based on a single medical image input. Hence, an abstract medical description or concept is hard to be generated based on the traditional approach. Such a method limits the effectiveness of medical image captioning. Multi-modal medical image captioning is one of the approaches utilized to address this problem. In multi-modal medical image captioning, textual input, e.g., expert-defined keywords, is considered as one of the main drivers of medical description generation. Thus, encoding the textual input and the medical image effectively are both important for the task of multi-modal medical image captioning. In this work, a new end-to-end deep multi-modal medical image captioning model is proposed. Contextualized keyword representations, textual feature reinforcement, and masked self-attention are used to develop the proposed approach. Based on the evaluation of the existing multi-modal medical image captioning dataset, experimental results show that the proposed model is effective with the increase of +53.2% in BLEU-avg and +18.6% in CIDEr, compared with the state-of-the-art method.
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Kinship verification is a long-standing research challenge in computer vision. The visual differences presented to the face have a significant effect on the recognition capabilities of the kinship systems. We argue that aggregating multiple visual knowledge can better describe the characteristics of the subject for precise kinship identification. Typically, the age-invariant features can represent more natural facial details. Such age-related transformations are essential for face recognition due to the biological effects of aging. However, the existing methods mainly focus on employing the single-view image features for kinship identification, while more meaningful visual properties such as race and age are directly ignored in the feature learning step. To this end, we propose a novel deep collaborative multi-modal learning (DCML) to integrate the underlying information presented in facial properties in an adaptive manner to strengthen the facial details for effective unsupervised kinship verification. Specifically, we construct a well-designed adaptive feature fusion mechanism, which can jointly leverage the complementary properties from different visual perspectives to produce composite features and draw greater attention to the most informative components of spatial feature maps. Particularly, an adaptive weighting strategy is developed based on a novel attention mechanism, which can enhance the dependencies between different properties by decreasing the information redundancy in channels in a self-adaptive manner. To validate the effectiveness of the proposed method, extensive experimental evaluations conducted on four widely-used datasets show that our DCML method is always superior to some state-of-the-art kinship verification methods.
Image annotation aims to annotate a given image with a variable number of class labels corresponding to diverse visual concepts. In this paper, we address two main issues in large-scale image annotation: 1) how to learn a rich feature representation suitable for predicting a diverse set of visual concepts ranging from object, scene to abstract concept; 2) how to annotate an image with the optimal number of class labels. To address the first issue, we propose a novel multi-scale deep model for extracting rich and discriminative features capable of representing a wide range of visual concepts. Specifically, a novel two-branch deep neural network architecture is proposed which comprises a very deep main network branch and a companion feature fusion network branch designed for fusing the multi-scale features computed from the main branch. The deep model is also made multi-modal by taking noisy user-provided tags as model input to complement the image input. For tackling the second issue, we introduce a label quantity prediction auxiliary task to the main label prediction task to explicitly estimate the optimal label number for a given image. Extensive experiments are carried out on two large-scale image annotation benchmark datasets and the results show that our method significantly outperforms the state-of-the-art.
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