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Extracting dispersion curves from ambient noise correlations using deep learning

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 Added by Zachary Ross
 Publication date 2020
and research's language is English




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We present a machine-learning approach to classifying the phases of surface wave dispersion curves. Standard FTAN analysis of surfaces observed on an array of receivers is converted to an image, of which, each pixel is classified as fundamental mode, first overtone, or noise. We use a convolutional neural network (U-net) architecture with a supervised learning objective and incorporate transfer learning. The training is initially performed with synthetic data to learn coarse structure, followed by fine-tuning of the network using approximately 10% of the real data based on human classification. The results show that the machine classification is nearly identical to the human picked phases. Expanding the method to process multiple images at once did not improve the performance. The developed technique will faciliate automated processing of large dispersion curve datasets.



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Quantitative analysis of cell structures is essential for biomedical and pharmaceutical research. The standard imaging approach relies on fluorescence microscopy, where cell structures of interest are labeled by chemical staining techniques. However, these techniques are often invasive and sometimes even toxic to the cells, in addition to being time-consuming, labor-intensive, and expensive. Here, we introduce an alternative deep-learning-powered approach based on the analysis of brightfield images by a conditional generative adversarial neural network (cGAN). We show that this approach can extract information from the brightfield images to generate virtually-stained images, which can be used in subsequent downstream quantitative analyses of cell structures. Specifically, we train a cGAN to virtually stain lipid droplets, cytoplasm, and nuclei using brightfield images of human stem-cell-derived fat cells (adipocytes), which are of particular interest for nanomedicine and vaccine development. Subsequently, we use these virtually-stained images to extract quantitative measures about these cell structures. Generating virtually-stained fluorescence images is less invasive, less expensive, and more reproducible than standard chemical staining; furthermore, it frees up the fluorescence microscopy channels for other analytical probes, thus increasing the amount of information that can be extracted from each cell.
68 - Y. D. Wang 2019
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