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Register a new userHepatocellular Carcinoma Intra-arterial Treatment Response Prediction for Improved Therapeutic Decision-Making
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This work proposes a pipeline to predict treatment response to intra-arterial therapy of patients with Hepatocellular Carcinoma (HCC) for improved therapeutic decision-making. Our graph neural network model seamlessly combines heterogeneous inputs of baseline MR scans, pre-treatment clinical information, and planned treatment characteristics and has been validated on patients with HCC treated by transarterial chemoembolization (TACE). It achieves Accuracy of $0.713 pm 0.075$, F1 of $0.702 pm 0.082$ and AUC of $0.710 pm 0.108$. In addition, the pipeline incorporates uncertainty estimation to select hard cases and most align with the misclassified cases. The proposed pipeline arrives at more informed intra-arterial therapeutic decisions for patients with HCC via improving model accuracy and incorporating uncertainty estimation.
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Automatic segmentation of hepatocellular carcinoma (HCC) in Digital Subtraction Angiography (DSA) videos can assist radiologists in efficient diagnosis of HCC and accurate evaluation of tumors in clinical practice. Few studies have investigated HCC segmentation from DSA videos. It shows great challenging due to motion artifacts in filming, ambiguous boundaries of tumor regions and high similarity in imaging to other anatomical tissues. In this paper, we raise the problem of HCC segmentation in DSA videos, and build our own DSA dataset. We also propose a novel segmentation network called DSA-LTDNet, including a segmentation sub-network, a temporal difference learning (TDL) module and a liver region segmentation (LRS) sub-network for providing additional guidance. DSA-LTDNet is preferable for learning the latent motion information from DSA videos proactively and boosting segmentation performance. All of experiments are conducted on our self-collected dataset. Experimental results show that DSA-LTDNet increases the DICE score by nearly 4% compared to the U-Net baseline.
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and the fourth most common cause of cancer-related death worldwide. Understanding the underlying gene mutations in HCC provides great prognostic value for treatment planning and targeted therapy. Radiogenomics has revealed an association between non-invasive imaging features and molecular genomics. However, imaging feature identification is laborious and error-prone. In this paper, we propose an end-to-end deep learning framework for mutation prediction in APOB, COL11A1 and ATRX genes using multiphasic CT scans. Considering intra-tumour heterogeneity (ITH) in HCC, multi-region sampling technology is implemented to generate the dataset for experiments. Experimental results demonstrate the effectiveness of the proposed model.
Gene mutation prediction in hepatocellular carcinoma (HCC) is of great diagnostic and prognostic value for personalized treatments and precision medicine. In this paper, we tackle this problem with multi-instance multi-label learning to address the difficulties on label correlations, label representations, etc. Furthermore, an effective oversampling strategy is applied for data imbalance. Experimental results have shown the superiority of the proposed approach.
Advances in deep learning (DL) have resulted in impressive accuracy in some medical image classification tasks, but often deep models lack interpretability. The ability of these models to explain their decisions is important for fostering clinical trust and facilitating clinical translation. Furthermore, for many problems in medicine there is a wealth of existing clinical knowledge to draw upon, which may be useful in generating explanations, but it is not obvious how this knowledge can be encoded into DL models - most models are learnt either from scratch or using transfer learning from a different domain. In this paper we address both of these issues. We propose a novel DL framework for image-based classification based on a variational autoencoder (VAE). The framework allows prediction of the output of interest from the latent space of the autoencoder, as well as visualisation (in the image domain) of the effects of crossing the decision boundary, thus enhancing the interpretability of the classifier. Our key contribution is that the VAE disentangles the latent space based on `explanations drawn from existing clinical knowledge. The framework can predict outputs as well as explanations for these outputs, and also raises the possibility of discovering new biomarkers that are separate (or disentangled) from the existing knowledge. We demonstrate our framework on the problem of predicting response of patients with cardiomyopathy to cardiac resynchronization therapy (CRT) from cine cardiac magnetic resonance images. The sensitivity and specificity of the proposed model on the task of CRT response prediction are 88.43% and 84.39% respectively, and we showcase the potential of our model in enhancing understanding of the factors contributing to CRT response.
Nasopharyngeal Carcinoma (NPC) is a worldwide malignant epithelial cancer. Survival prediction is a major concern for NPC patients, as it provides early prognostic information that is needed to guide treatments. Recently, deep learning, which leverages Deep Neural Networks (DNNs) to learn deep representations of image patterns, has been introduced to the survival prediction in various cancers including NPC. It has been reported that image-derived end-to-end deep survival models have the potential to outperform clinical prognostic indicators and traditional radiomics-based survival models in prognostic performance. However, deep survival models, especially 3D models, require large image training data to avoid overfitting. Unfortunately, medical image data is usually scarce, especially for Positron Emission Tomography/Computed Tomography (PET/CT) due to the high cost of PET/CT scanning. Compared to Magnetic Resonance Imaging (MRI) or Computed Tomography (CT) providing only anatomical information of tumors, PET/CT that provides both anatomical (from CT) and metabolic (from PET) information is promising to achieve more accurate survival prediction. However, we have not identified any 3D end-to-end deep survival model that applies to small PET/CT data of NPC patients. In this study, we introduced the concept of multi-task leaning into deep survival models to address the overfitting problem resulted from small data. Tumor segmentation was incorporated as an auxiliary task to enhance the models efficiency of learning from scarce PET/CT data. Based on this idea, we proposed a 3D end-to-end Deep Multi-Task Survival model (DeepMTS) for joint survival prediction and tumor segmentation. Our DeepMTS can jointly learn survival prediction and tumor segmentation using PET/CT data of only 170 patients with advanced NPC.
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