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Register a new userOnline Debiasing for Adaptively Collected High-dimensional Data with Applications to Time Series Analysis
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Adaptive collection of data is commonplace in applications throughout science and engineering. From the point of view of statistical inference however, adaptive data collection induces memory and correlation in the samples, and poses significant challenge. We consider the high-dimensional linear regression, where the samples are collected adaptively, and the sample size $n$ can be smaller than $p$, the number of covariates. In this setting, there are two distinct sources of bias: the first due to regularization imposed for consistent estimation, e.g. using the LASSO, and the second due to adaptivity in collecting the samples. We propose online debiasing, a general procedure for estimators such as the LASSO, which addresses both sources of bias. In two concrete contexts $(i)$ time series analysis and $(ii)$ batched data collection, we demonstrate that online debiasing optimally debiases the LASSO estimate when the underlying parameter $theta_0$ has sparsity of order $o(sqrt{n}/log p)$. In this regime, the debiased estimator can be used to compute $p$-values and confidence intervals of optimal size.
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Learning optimal policies from historical data enables the gains from personalization to be realized in a wide variety of applications. The growing policy learning literature focuses on a setting where the treatment assignment policy does not adapt to the data. However, adaptive data collection is becoming more common in practice, from two primary sources: 1) data collected from adaptive experiments that are designed to improve inferential efficiency; 2) data collected from production systems that are adaptively evolving an operational policy to improve performance over time (e.g. contextual bandits). In this paper, we aim to address the challenge of learning the optimal policy with adaptively collected data and provide one of the first theoretical inquiries into this problem. We propose an algorithm based on generalized augmented inverse propensity weighted estimators and establish its finite-sample regret bound. We complement this regret upper bound with a lower bound that characterizes the fundamental difficulty of policy learning with adaptive data. Finally, we demonstrate our algorithms effectiveness using both synthetic data and public benchmark datasets.
From scientific experiments to online A/B testing, the previously observed data often affects how future experiments are performed, which in turn affects which data will be collected. Such adaptivity introduces complex correlations between the data and the collection procedure. In this paper, we prove that when the data collection procedure satisfies natural conditions, then sample means of the data have systematic emph{negative} biases. As an example, consider an adaptive clinical trial where additional data points are more likely to be tested for treatments that show initial promise. Our surprising result implies that the average observed treatment effects would underestimate the true effects of each treatment. We quantitatively analyze the magnitude and behavior of this negative bias in a variety of settings. We also propose a novel debiasing algorithm based on selective inference techniques. In experiments, our method can effectively reduce bias and estimation error.
Topological Data Analysis (TDA) is a rapidly growing field, which studies methods for learning underlying topological structures present in complex data representations. TDA methods have found recent success in extracting useful geometric structures for a wide range of applications, including protein classification, neuroscience, and time-series analysis. However, in many such applications, one is also interested in sequentially detecting changes in this topological structure. We propose a new method called Persistence Diagram based Change-Point (PD-CP), which tackles this problem by integrating the widely-used persistence diagrams in TDA with recent developments in nonparametric change-point detection. The key novelty in PD-CP is that it leverages the distribution of points on persistence diagrams for online detection of topological changes. We demonstrate the effectiveness of PD-CP in an application to solar flare monitoring.
Bandit algorithms are increasingly used in real-world sequential decision-making problems. Associated with this is an increased desire to be able to use the resulting datasets to answer scientific questions like: Did one type of ad lead to more purchases? In which contexts is a mobile health intervention effective? However, classical statistical approaches fail to provide valid confidence intervals when used with data collected with bandit algorithms. Alternative methods have recently been developed for simple models (e.g., comparison of means). Yet there is a lack of general methods for conducting statistical inference using more complex models on data collected with (contextual) bandit algorithms; for example, current methods cannot be used for valid inference on parameters in a logistic regression model for a binary reward. In this work, we develop theory justifying the use of M-estimators -- which includes estimators based on empirical risk minimization as well as maximum likelihood -- on data collected with adaptive algorithms, including (contextual) bandit algorithms. Specifically, we show that M-estimators, modified with particular adaptive weights, can be used to construct asymptotically valid confidence regions for a variety of inferential targets.
An important problem in analysis of neural data is to characterize interactions across brain regions from high-dimensional multiple-electrode recordings during a behavioral experiment. Lead-lag effects indicate possible directional flows of neural information, but they are often transient, appearing during short intervals of time. Such non-stationary interactions can be difficult to identify, but they can be found by taking advantage of the replication structure inherent to many neurophysiological experiments. To describe non-stationary interactions between replicated pairs of high-dimensional time series, we developed a method of estimating latent, non-stationary cross-correlation. Our approach begins with an extension of probabilistic CCA to the time series setting, which provides a model-based interpretation of multiset CCA. Because the covariance matrix describing non-stationary dependence is high-dimensional, we assume sparsity of cross-correlations within a range of possible interesting lead-lag effects. We show that the method can perform well in realistic settings and we apply it to 192 simultaneous local field potential (LFP) recordings from prefrontal cortex (PFC) and visual cortex (area V4) during a visual memory task. We find lead-lag relationships that are highly plausible, being consistent with related results in the literature.
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