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Register a new userDeep Reinforcement Learning for Clinical Decision Support: A Brief Survey
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Siqi Liu
Publication date
2019
fields
Informatics Engineering
and research's language is
English
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Owe to the recent advancements in Artificial Intelligence especially deep learning, many data-driven decision support systems have been implemented to facilitate medical doctors in delivering personalized care. We focus on the deep reinforcement learning (DRL) models in this paper. DRL models have demonstrated human-level or even superior performance in the tasks of computer vision and game playings, such as Go and Atari game. However, the adoption of deep reinforcement learning techniques in clinical decision optimization is still rare. We present the first survey that summarizes reinforcement learning algorithms with Deep Neural Networks (DNN) on clinical decision support. We also discuss some case studies, where different DRL algorithms were applied to address various clinical challenges. We further compare and contrast the advantages and limitations of various DRL algorithms and present a preliminary guide on how to choose the appropriate DRL algorithm for particular clinical applications.
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Reinforcement Learning (RL) is a key technique to address sequential decision-making problems and is crucial to realize advanced artificial intelligence. Recent years have witnessed remarkable progress in RL by virtue of the fast development of deep neural networks. Along with the promising prospects of RL in numerous domains, such as robotics and game-playing, transfer learning has arisen as an important technique to tackle various challenges faced by RL, by transferring knowledge from external expertise to accelerate the learning process. In this survey, we systematically investigate the recent progress of transfer learning approaches in the context of deep reinforcement learning. Specifically, we provide a framework for categorizing the state-of-the-art transfer learning approaches, under which we analyze their goals, methodologies, compatible RL backbones, and practical applications. We also draw connections between transfer learning and other relevant topics from the RL perspective and explore their potential challenges as well as open questions that await future research progress.
The pervasive application of algorithmic decision-making is raising concerns on the risk of unintended bias in AI systems deployed in critical settings such as healthcare. The detection and mitigation of biased models is a very delicate task which should be tackled with care and involving domain experts in the loop. In this paper we introduce FairLens, a methodology for discovering and explaining biases. We show how our tool can be used to audit a fictional commercial black-box model acting as a clinical decision support system. In this scenario, the healthcare facility experts can use FairLens on their own historical data to discover the models biases before incorporating it into the clinical decision flow. FairLens first stratifies the available patient data according to attributes such as age, ethnicity, gender and insurance; it then assesses the model performance on such subgroups of patients identifying those in need of expert evaluation. Finally, building on recent state-of-the-art XAI (eXplainable Artificial Intelligence) techniques, FairLens explains which elements in patients clinical history drive the model error in the selected subgroup. Therefore, FairLens allows experts to investigate whether to trust the model and to spotlight group-specific biases that might constitute potential fairness issues.
With the development of deep representation learning, the domain of reinforcement learning (RL) has become a powerful learning framework now capable of learning complex policies in high dimensional environments. This review summarises deep reinforcement learning (DRL) algorithms and provides a taxonomy of automated driving tasks where (D)RL methods have been employed, while addressing key computational challenges in real world deployment of autonomous driving agents. It also delineates adjacent domains such as behavior cloning, imitation learning, inverse reinforcement learning that are related but are not classical RL algorithms. The role of simulators in training agents, methods to validate, test and robustify existing solutions in RL are discussed.
Sequential decision making, commonly formalized as Markov Decision Process (MDP) optimization, is a key challenge in artificial intelligence. Two key approaches to this problem are reinforcement learning (RL) and planning. This paper presents a survey of the integration of both fields, better known as model-based reinforcement learning. Model-based RL has two main steps. First, we systematically cover approaches to dynamics model learning, including challenges like dealing with stochasticity, uncertainty, partial observability, and temporal abstraction. Second, we present a systematic categorization of planning-learning integration, including aspects like: where to start planning, what budgets to allocate to planning and real data collection, how to plan, and how to integrate planning in the learning and acting loop. After these two section, we also discuss implicit model-based RL as an end-to-end alternative for model learning and planning, and we cover the potential benefits of model-based RL, like enhanced data efficiency, targeted exploration, and improved stability. The survey also draws connection to several related RL fields, like hierarchical RL and transfer. Altogether, the survey presents a broad conceptual overview of planning-learning combinations for MDP optimization.
Data in real-world application often exhibit skewed class distribution which poses an intense challenge for machine learning. Conventional classification algorithms are not effective in the case of imbalanced data distribution, and may fail when the data distribution is highly imbalanced. To address this issue, we propose a general imbalanced classification model based on deep reinforcement learning. We formulate the classification problem as a sequential decision-making process and solve it by deep Q-learning network. The agent performs a classification action on one sample at each time step, and the environment evaluates the classification action and returns a reward to the agent. The reward from minority class sample is larger so the agent is more sensitive to the minority class. The agent finally finds an optimal classification policy in imbalanced data under the guidance of specific reward function and beneficial learning environment. Experiments show that our proposed model outperforms the other imbalanced classification algorithms, and it can identify more minority samples and has great classification performance.
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