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Register a new userGAMENet: Graph Augmented MEmory Networks for Recommending Medication Combination
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Junyuan Shang
Publication date
2018
fields
Informatics Engineering
and research's language is
English
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Recent progress in deep learning is revolutionizing the healthcare domain including providing solutions to medication recommendations, especially recommending medication combination for patients with complex health conditions. Existing approaches either do not customize based on patient health history, or ignore existing knowledge on drug-drug interactions (DDI) that might lead to adverse outcomes. To fill this gap, we propose the Graph Augmented Memory Networks (GAMENet), which integrates the drug-drug interactions knowledge graph by a memory module implemented as a graph convolutional networks, and models longitudinal patient records as the query. It is trained end-to-end to provide safe and personalized recommendation of medication combination. We demonstrate the effectiveness and safety of GAMENet by comparing with several state-of-the-art methods on real EHR data. GAMENet outperformed all baselines in all effectiveness measures, and also achieved 3.60% DDI rate reduction from existing EHR data.
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Medication recommendation is an important healthcare application. It is commonly formulated as a temporal prediction task. Hence, most existing works only utilize longitudinal electronic health records (EHRs) from a small number of patients with multiple visits ignoring a large number of patients with a single visit (selection bias). Moreover, important hierarchical knowledge such as diagnosis hierarchy is not leveraged in the representation learning process. To address these challenges, we propose G-BERT, a new model to combine the power of Graph Neural Networks (GNNs) and BERT (Bidirectional Encoder Representations from Transformers) for medical code representation and medication recommendation. We use GNNs to represent the internal hierarchical structures of medical codes. Then we integrate the GNN representation into a transformer-based visit encoder and pre-train it on EHR data from patients only with a single visit. The pre-trained visit encoder and representation are then fine-tuned for downstream predictive tasks on longitudinal EHRs from patients with multiple visits. G-BERT is the first to bring the language model pre-training schema into the healthcare domain and it achieved state-of-the-art performance on the medication recommendation task.
Human intelligence is characterized by a remarkable ability to infer abstract rules from experience and apply these rules to novel domains. As such, designing neural network algorithms with this capacity is an important step toward the development of deep learning systems with more human-like intelligence. However, doing so is a major outstanding challenge, one that some argue will require neural networks to use explicit symbol-processing mechanisms. In this work, we focus on neural networks capacity for arbitrary role-filler binding, the ability to associate abstract roles to context-specific fillers, which many have argued is an important mechanism underlying the ability to learn and apply rules abstractly. Using a simplified version of Ravens Progressive Matrices, a hallmark test of human intelligence, we introduce a sequential formulation of a visual problem-solving task that requires this form of binding. Further, we introduce the Emergent Symbol Binding Network (ESBN), a recurrent neural network model that learns to use an external memory as a binding mechanism. This mechanism enables symbol-like variable representations to emerge through the ESBNs training process without the need for explicit symbol-processing machinery. We empirically demonstrate that the ESBN successfully learns the underlying abstract rule structure of our task and perfectly generalizes this rule structure to novel fillers.
Traditional neural networks require enormous amounts of data to build their complex mappings during a slow training procedure that hinders their abilities for relearning and adapting to new data. Memory-augmented neural networks enhance neural networks with an explicit memory to overcome these issues. Access to this explicit memory, however, occurs via soft read and write operations involving every individual memory entry, resulting in a bottleneck when implemented using the conventional von Neumann computer architecture. To overcome this bottleneck, we propose a robust architecture that employs a computational memory unit as the explicit memory performing analog in-memory computation on high-dimensional (HD) vectors, while closely matching 32-bit software-equivalent accuracy. This is achieved by a content-based attention mechanism that represents unrelated items in the computational memory with uncorrelated HD vectors, whose real-valued components can be readily approximated by binary, or bipolar components. Experimental results demonstrate the efficacy of our approach on few-shot image classification tasks on the Omniglot dataset using more than 256,000 phase-change memory devices. Our approach effectively merges the richness of deep neural network representations with HD computing that paves the way for robust vector-symbolic manipulations applicable in reasoning, fusion, and compression.
A common challenge for most current recommender systems is the cold-start problem. Due to the lack of user-item interactions, the fine-tuned recommender systems are unable to handle situations with new users or new items. Recently, some works introduce the meta-optimization idea into the recommendation scenarios, i.e. predicting the user preference by only a few of past interacted items. The core idea is learning a global sharing initialization parameter for all users and then learning the local parameters for each user separately. However, most meta-learning based recommendation approaches adopt model-agnostic meta-learning for parameter initialization, where the global sharing parameter may lead the model into local optima for some users. In this paper, we design two memory matrices that can store task-specific memories and feature-specific memories. Specifically, the feature-specific memories are used to guide the model with personalized parameter initialization, while the task-specific memories are used to guide the model fast predicting the user preference. And we adopt a meta-optimization approach for optimizing the proposed method. We test the model on two widely used recommendation datasets and consider four cold-start situations. The experimental results show the effectiveness of the proposed methods.
Poor medication adherence presents serious economic and health problems including compromised treatment effectiveness, medical complications, and loss of billions of dollars in wasted medicine or procedures. Though various interventions have been proposed to address this problem, there is an urgent need to leverage light, smart, and minimally obtrusive technology such as smartwatches to develop user tools to improve medication use and adherence. In this study, we conducted several experiments on medication-taking activities, developed a smartwatch android application to collect the accelerometer hand gesture data from the smartwatch, and conveyed the data collected to a central cloud database. We developed neural networks, then trained the networks on the sensor data to recognize medication and non-medication gestures. With the proposed machine learning algorithm approach, this study was able to achieve average accuracy scores of 97% on the protocol-guided gesture data, and 95% on natural gesture data.
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