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Register a new userOn a multi-species Cahn-Hilliard-Darcy tumor growth model with singular potentials
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We consider a model describing the evolution of a tumor inside a host tissue in terms of the parameters $varphi_p$, $varphi_d$ (proliferating and dead cells, respectively), $u$ (cell velocity) and $n$ (nutrient concentration). The variables $varphi_p$, $varphi_d$ satisfy a Cahn-Hilliard type system with nonzero forcing term (implying that their spatial means are not conserved in time), whereas $u$ obeys a form of the Darcy law and $n$ satisfies a quasistatic diffusion equation. The main novelty of the present work stands in the fact that we are able to consider a configuration potential of singular type implying that the concentration vector $(varphi_p,varphi_d)$ is constrained to remain in the range of physically admissible values. On the other hand, in view of the presence of nonzero forcing terms, this choice gives rise to a number of mathematical difficulties, especially related to the control of the mean values of $varphi_p$ and $varphi_d$. For the resulting mathematical problem, by imposing suitable initial-boundary conditions, our main result concerns the existence of weak solutions in a proper regularity class.
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We consider a Cahn-Hilliard equation which is the conserved gradient flow of a nonlocal total free energy functional. This functional is characterized by a Helmholtz free energy density, which can be of logarithmic type. Moreover, the spatial interactions between the different phases are modeled by a singular kernel. As a consequence, the chemical potential $mu$ contains an integral operator acting on the concentration difference $c$, instead of the usual Laplace operator. We analyze the equation on a bounded domain subject to no-flux boundary condition for $mu$ and by assuming constant mobility. We first establish the existence and uniqueness of a weak solution and some regularity properties. These results allow us to define a dissipative dynamical system on a suitable phase-space and we prove that such a system has a (connected) global attractor. Finally, we show that a Neumann-like boundary condition can be recovered for $c$, provided that it is supposed to be regular enough.
We consider a stochastic partial differential equation with logarithmic (or negative power) nonlinearity, with one reflection at 0 and with a constraint of conservation of the space average. The equation, driven by the derivative in space of a space-time white noise, contains a bi-Laplacian in the drift. The lack of the maximum principle for the bi-Laplacian generates difficulties for the classical penalization method, which uses a crucial monotonicity property. Being inspired by the works of Debussche and Zambotti, we use a method based on infinite dimensional equations, approximation by regular equations and convergence of the approximated semi-group. We obtain existence and uniqueness of solution for nonnegative intial conditions, results on the invariant measures, and on the reflection measures.
We study a diffuse interface model describing the evolution of the flow of a binary fluid in a Hele-Shaw cell. The model consists of a Cahn-Hilliard-Darcy (CHD) type system with transport and mass source. A relevant physical application is related to tumor growth dynamics, which in particular justifies the occurrence of a mass inflow. We study the initial-boundary value problem for this model and prove global existence and uniqueness of strong solutions in two space dimensions as well as local existence in three space dimensions.
We consider a relaxation of the viscous Cahn-Hilliard equation induced by the second-order inertial term~$u_{tt}$. The equation also contains a semilinear term $f(u)$ of singular type. Namely, the function $f$ is defined only on a bounded interval of ${mathbb R}$ corresponding to the physically admissible values of the unknown $u$, and diverges as $u$ approaches the extrema of that interval. In view of its interaction with the inertial term $u_{tt}$, the term $f(u)$ is difficult to be treated mathematically. Based on an approach originally devised for the strongly damped wave equation, we propose a suitable concept of weak solution based on duality methods and prove an existence result.
In this paper we perform an asymptotic analysis for two different vanishing viscosity coefficients occurring in a phase field system of Cahn-Hilliard type that was recently introduced in order to approximate a tumor growth model. In particular, we extend some recent results obtained in the preprint arXiv:1401.5943, letting the two positive viscosity parameters tend to zero independently from each other and weakening the conditions on the initial data in such a way as to maintain the nonlinearities of the PDE system as general as possible. Finally, under proper growth conditions on the interaction potential, we prove an error estimate leading also to the uniqueness result for the limit system.
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