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Register a new userIdentifiability of directed Gaussian graphical models with one latent source
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Dennis Leung
Publication date
2015
fields
Mathematical Statistics
and research's language is
English
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We study parameter identifiability of directed Gaussian graphical models with one latent variable. In the scenario we consider, the latent variable is a confounder that forms a source node of the graph and is a parent to all other nodes, which correspond to the observed variables. We give a graphical condition that is sufficient for the Jacobian matrix of the parametrization map to be full rank, which entails that the parametrization is generically finite-to-one, a fact that is sometimes also referred to as local identifiability. We also derive a graphical condition that is necessary for such identifiability. Finally, we give a condition under which generic parameter identifiability can be determined from identifiability of a model associated with a subgraph. The power of these criteria is assessed via an exhaustive algebraic computational study on models with 4, 5, and 6 observable variables.
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While hidden class models of various types arise in many statistical applications, it is often difficult to establish the identifiability of their parameters. Focusing on models in which there is some structure of independence of some of the observed variables conditioned on hidden ones, we demonstrate a general approach for establishing identifiability utilizing algebraic arguments. A theorem of J. Kruskal for a simple latent-class model with finite state space lies at the core of our results, though we apply it to a diverse set of models. These include mixtures of both finite and nonparametric product distributions, hidden Markov models and random graph mixture models, and lead to a number of new results and improvements to old ones. In the parametric setting, this approach indicates that for such models, the classical definition of identifiability is typically too strong. Instead generic identifiability holds, which implies that the set of nonidentifiable parameters has measure zero, so that parameter inference is still meaningful. In particular, this sheds light on the properties of finite mixtures of Bernoulli products, which have been used for decades despite being known to have nonidentifiable parameters. In the nonparametric setting, we again obtain identifiability only when certain restrictions are placed on the distributions that are mixed, but we explicitly describe the conditions.
Directed graphical models specify noisy functional relationships among a collection of random variables. In the Gaussian case, each such model corresponds to a semi-algebraic set of positive definite covariance matrices. The set is given via parametrization, and much work has gone into obtaining an implicit description in terms of polynomial (in-)equalities. Implicit descriptions shed light on problems such as parameter identification, model equivalence, and constraint-based statistical inference. For models given by directed acyclic graphs, which represent settings where all relevant variables are observed, there is a complete theory: All conditional independence relations can be found via graphical $d$-separation and are sufficient for an implicit description. The situation is far more complicated, however, when some of the variables are hidden (or in other words, unobserved or latent). We consider models associated to mixed graphs that capture the effects of hidden variables through correlated error terms. The notion of trek separation explains when the covariance matrix in such a model has submatrices of low rank and generalizes $d$-separation. However, in many cases, such as the infamous Verma graph, the polynomials defining the graphical model are not determinantal, and hence cannot be explained by $d$-separation or trek-separation. In this paper, we show that these constraints often correspond to the vanishing of nested determinants and can be graphically explained by a notion of restricted trek separation.
Gaussian Graphical models (GGM) are widely used to estimate the network structures in many applications ranging from biology to finance. In practice, data is often corrupted by latent confounders which biases inference of the underlying true graphical structure. In this paper, we compare and contrast two strategies for inference in graphical models with latent confounders: Gaussian graphical models with latent variables (LVGGM) and PCA-based removal of confounding (PCA+GGM). While these two approaches have similar goals, they are motivated by different assumptions about confounding. In this paper, we explore the connection between these two approaches and propose a new method, which combines the strengths of these two approaches. We prove the consistency and convergence rate for the PCA-based method and use these results to provide guidance about when to use each method. We demonstrate the effectiveness of our methodology using both simulations and in two real-world applications.
In the last decade, the secondary use of large data from health systems, such as electronic health records, has demonstrated great promise in advancing biomedical discoveries and improving clinical decision making. However, there is an increasing concern about biases in association studies caused by misclassification in the binary outcomes derived from electronic health records. We revisit the classical logistic regression model with misclassified outcomes. Despite that local identification conditions in some related settings have been previously established, the global identification of such models remains largely unknown and is an important question yet to be answered. We derive necessary and sufficient conditions for global identifiability of logistic regression models with misclassified outcomes, using a novel approach termed as the submodel analysis, and a technique adapted from the Picard-Lindel{o}f existence theorem in ordinary differential equations. In particular, our results are applicable to logistic models with discrete covariates, which is a common situation in biomedical studies, The conditions are easy to verify in practice. In addition to model identifiability, we propose a hypothesis testing procedure for regression coefficients in the misclassified logistic regression model when the model is not identifiable under the null.
Discussion of Latent variable graphical model selection via convex optimization by Venkat Chandrasekaran, Pablo A. Parrilo and Alan S. Willsky [arXiv:1008.1290].
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