A study of the effect of electrostatic charge that is generated in actuator due to drying methods on the delivered dose of metered dose inhaler has been done in tow cases:
Washing actuator and drying it by a clothe.
Washing actuator and let it dry
alone.
A study has been done on metered dose inhaler containing salbutmaol sulfate and manufactured by a local company.
The results show the importance of drying methods on the delivered dose, the delivered doses of metered dose inhaler after washing the actuator and dry it by a clothe hadn't been achieved the USP-34 requirements (out of range 75-125%), while the delivered doses after washing actuator and let it dry alone had been achieved the USP-34 requirements.
The difference in results between the two cases belong to electrostatic charge generated in actuator due to drying methods
