Study of the Epitope Mapping and Igg Sub-Classes of Anti-Factor VIII Antibodies in Patients with Haemophilia A

Background& Objective: The development of inhibitors (Antibody against factor VIII ant-FVIII) is currently one of the major complications for the treatment of patients with hemophilia A, The only effective treatment available today when they appearis Immune Tolerance Induction ITI, There is no to the present any laboratory predictor of response to this worrying and expensive treatment. This research aims to study the epitope mapping and identification of IgG sub-classes of factor FVIII inhibitors to study the immune response against factor VIII in patients with hemophilia A.