The aim of the present study is to prepare extended hard capsules of furosemide using
Eudragit RL, Eudragit RS and Ethyl cellulose individually and in different ratios (6,8,12 and
15%). The granules were prepared by wet granulation using isopropyl
alcohol as a
granulating agent and then filled into capsules. The influence of different concentrations and
type of polymer was studied. The prepared capsules assessed for their physicochemical
properties and in-vitro drug release studies. In vitro release data show that Ethyl cellulose
has more retardation than Eudragits, and Eudragit RS retards drug more than Eudragit RL
does. Furthermore, higher concentration of polymer tends to more retardation than lower
concentration.
