The aim of this paper is to determine the best optical-probe
geometry that would help to detect neoplastic lesions in oral
epithelial tissue. Two Geometrical configurations are investigated.
The first one implements different distances between the
illumination and collection fibers, and the second one implements
different fiber diameters.
Both of these geometries are evaluated for their collection efficiency
and depth resolution. The effect of numerical aperture (NA) and
tissue optical properties on the fluorescence signal are also studied.
Optical properties of dysplastic tongue epithelial multi-layered
tissue were used as an input for Monte Carlo simulation. The results
show that the sensitivity to superficial layers can be achieved using
small fiber diameters. On the contrary, the sensitivity to deeper
layers can be achieved using larger distances between illumination
and collection fibers.
