ترغب بنشر مسار تعليمي؟ اضغط هنا

Large-scales patterns in a minimal cognitive flocking model: incidental leaders, nematic patterns, and aggregates

400   0   0.0 ( 0 )
 نشر من قبل Fernando Peruani
 تاريخ النشر 2019
  مجال البحث فيزياء
والبحث باللغة English




اسأل ChatGPT حول البحث

We study a minimal cognitive flocking model, which assumes that the moving entities navigate using exclusively the available instantaneous visual information. The model consists of active particles, with no memory, that interact by a short-ranged, position-based, attractive force that acts inside a vision cone (VC) and lack velocity-velocity alignment. We show that this active system can exhibit -- due to the VC that breaks Newtons third law -- various complex, large-scale, self-organized patterns. Depending on parameter values, we observe the emergence of aggregates or milling-like patterns, the formation of moving -- locally polar -- files with particles at the front of these structures acting as effective leaders, and the self-organization of particles into macroscopic nematic structures leading to long-ranged nematic order. Combining simulations and non-linear field equations, we show that position-based active models, as the one analyzed here, represent a new class of active systems fundamentally different from other active systems, including velocity-alignment-based flocking systems. The reported results are of prime importance in the study, interpretation, and modeling of collective motion patterns in living and non-living active systems.

قيم البحث

اقرأ أيضاً

179 - Fernando Peruani 2019
The spontaneous emergence of collective motion patterns is usually associated with the presence of a velocity alignment mechanism that mediates the interactions among the moving individuals. Despite of this widespread view, it has been shown recently that several flocking behaviors can emerge in the absence of velocity alignment and as a result of short-range, position-based, attractive forces that act inside a vision cone. Here, we derive the corresponding hydrodynamic equations of a microscopic position-based flocking model, reviewing and extending previously reported results. In particular, we show that three distinct macroscopic collective behaviors can be observed: i) the coarsening of aggregates with no orientational order, ii) the emergence of static, elongated nematic bands, and iii) the formation of moving, locally polar structures, which we call worms. The derived hydrodynamic equations indicate that active particles interacting via position-based interactions belong to a distinct class of active systems fundamentally different from other active systems, including velocity-alignment-based flocking systems.
Several different enzymes display an apparent diffusion coefficient that increases with the concentration of their substrate. Moreover, their motion becomes directed in substrate gradients. Currently, there are several competing models for these tran sport dynamics. Here, we analyze whether the enzymatic reactions can generate a significant feedback from enzyme transport onto the substrate profile. We find that this feedback can generate spatial patterns in the enzyme distribution, with just a single-step catalytic reaction. However, patterns are formed only for a subclass of transport models. For such models, nonspecific repulsive interactions between the enzyme and the substrate cause the enzyme to accumulate in regions of low substrate concentration. Reactions then amplify local substrate fluctuations, causing enzymes to further accumulate where substrate is low. Experimental analysis of this pattern formation process could discriminate between different transport models.
A stochastic version of the Barkai-Leibler model of chemotaxis receptors in {it E. coli} is studied here to elucidate the effects of intrinsic network noise in their conformational dynamics. It was originally proposed to explain the robust and near-p erfect adaptation of {it E. coli} observed across a wide range of spatially uniform attractant/repellent (ligand) concentrations. A receptor is either active or inactive and can stochastically switch between the two states. Enzyme CheR methylates inactive receptors while CheB demethylates active ones and the probability for it to be active depends on its level of methylation and ligandation. A simple version of the model with two methylation sites per receptor (M=2) shows zero-order ultrasensitivity (ZOU) akin to the classical 2-state model of covalent modification studied by Goldbeter and Koshland (GK). For extremely small and large ligand concentrations, the system reduces to two 2-state GK modules. A quantitative measure of the spontaneous fluctuations in activity (variance) estimated mathematically under linear noise approximation (LNA) is found to peak near the ZOU transition. The variance is a weak, non-monotonic and decreasing functions of ligand and receptor concentrations. Gillespie simulations for M=2 show excellent agreement with analytical results obtained under LNA. Numerical results for M=2, 3 and 4 show ZOU in mean activity; the variance is found to be smaller for larger M. The magnitude of receptor noise deduced from available experimental data is consistent with our predictions. A simple analysis of the downstream signaling pathway shows that this noise is large enough to have a beneficial effect on the motility of the organism. The response of mean receptor activity to small time-dependent changes in the external ligand concentration, computed within linear response theory, is found to have a bilobe form.
We develop a microscopic biophysical model for self-organization and reshaping of artificial tissue, that is co-driven by microscopic active forces between cells and extracellular matrix (ECM), and macroscopic forces that develop within the tissue, f inding close agreement with experiment. Microscopic active forces are stimulated by $mu$m scale interactions between cells and the ECM within which they exist, and when large numbers of cells act together these forces drive, and are affected by, macroscopic-scale self-organization and reshaping of tissues in a feedback loop. To understand this loop, there is a need to: (1) construct microscopic biophysical models that can simulate these processes for the very large number of cells found in tissues; (2) validate and calibrate those models against experimental data; and (3) understand the active feedback between cells and the extracellular matrix, and its relationship to macroscopic self-organization and reshaping of tissue. Our microscopic biophysical model consists of a contractile network representing the ECM, that interacts with a large number of cells via dipole forces, to describe macroscopic self-organization and reshaping of tissue. We solve the model using simulated annealing, finding close agreement with experiments on artificial neural tissue. We discuss calibration of model parameters. We conclude that feedback between microscopic cell-ECM dipole interactions and tissue-scale forces, is a key factor in driving macroscopic self-organization and reshaping of tissue. We discuss application of the biophysical model to simulation and rational design of artificial tissues.
We consider a model of an extensible semiflexible filament moving in two dimensions on a motility assay of motor proteins represented explicitly as active harmonic linkers. Their heads bind stochastically to polymer segments within a capture radius, and extend along the filament in a directed fashion before detaching. Both the extension and detachment rates are load-dependent and generate an active drive on the filament. The filament undergoes a first order phase transition from open chain to spiral conformations and shows a reentrant behavior in both the active extension and the turnover, defined as the ratio of attachment-detachment rates. Associated with the phase transition, the size and shape of the polymer changes non-monotonically, and the relevant autocorrelation functions display double-exponential decay. The corresponding correlation times show a maximum signifying the dominance of spirals. The orientational dynamics captures the rotation of spirals, and its correlation time decays with activity as a power law.
التعليقات
جاري جلب التعليقات جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا