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تسجيل مستخدم جديدUniversal spectrum for DNA base C+G concentration variability in Human chromosome Y
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A. M. Selvam
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The spatial distribution of DNA base sequence A, C, G and T exhibit selfsimilar fractal fluctuations and the corresponding power spectra follow inverse power law form, which implies the following: (1) A scale invariant eddy continuum, namely, the amplitudes of component eddies are related to each other by a scale factor alone. In general, the scale factor is different for different scale ranges and indicates a multifractal structure for the spatial distribution of DNA base sequence. (2) Long-range spatial correlations of the eddy fluctuations. Multifractal structure to space-time fluctuations and the associated inverse power law form for power spectra is generic to spatially extended dynamical systems in nature and is a signature of self-organized criticality. The exact physical mechanism for the observed self-organized criticality is not yet identified. The author has developed a general systems theory where quantum mechanical laws emerge as self-consistent explanations for the observed long-range space-time correlations, i.e. the apparently chaotic fractal fluctuations are signatures of quantum-like chaos in dynamical systems. The model provides unique quantification for the observed inverse power law form for power spectra in terms of the statistical normal distribution. In this paper it is shown that the frequency distribution of the bases C+G in all available contiguous sequences for Human chromosome Y DNA exhibit model predicted quantum-like chaos.
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Power spectra of human DNA base C+G frequency distribution in all available contiguous sections exhibit the universal inverse power law form of the statistical normal distribution for the 24 chromosomes. Inverse power law form for power spectra of sp
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rent assembly. A methodology for ranking the sequences based on deviation from average values of FD and SE was developed. The group of sequences scored among the 10% largest deviations had abnormally high likelihood to be from centromeric or pseudoautosomal regions and low likelihood to be from X-chromosome transposed regions. lncRNA sequences were also enriched among the outliers. In addition, the number of expressed genes previously identified for evolutionary study tended to not have large deviations from the average. Keywords: Y-chromosome; Shannon di-nucleotide entropy; fractal dimension; centromeric genes; gene degredation; lncRNA
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