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Alterations in the human gut bacteriome can be associated with human health issues, such as type-2 diabetes and cardiovascular disease. Both external and internal factors can drive changes in the composition and in the interactions of the human gut bacteriome, impacting negatively on the host cells. In this paper, we focus on the human gut bacteriome metabolism and we propose a two-layer network system to investigate its dynamics. Furthermore, we develop an in-silico simulation model (virtual GB), allowing us to study the impact of the metabolite exchange through molecular communications in the human gut bacteriome network system. Our results show that the regulation of molecular inputs can strongly affect bacterial population growth and create an unbalanced network, as shown by the shift in the node weights based on the molecular signals that are produced. Additionally, we show that the metabolite molecular communication production is greatly affected when directly manipulating the composition of the human gut bacteriome network in the virtual GB. These results indicate that our human GB interaction model can help to identify hidden behaviors of the human gut bacteriome depending on the molecular signal interactions. Moreover, the virtual GB can support the research and development of novel medical treatments based on the accurate control of bacterial growth and exchange of metabolites.
A system-level framework of complex microbe-microbe and host-microbe chemical cross-talk would help elucidate the role of our gut microbiota in health and disease. Here we report a literature-curated interspecies network of the human gut microbiota,
Significant inter-symbol interference (ISI) challenges the achievement of reliable, high data-rate molecular communication via diffusion. In this paper, a hybrid modulation based on pulse position and concentration is proposed to mitigate ISI. By exp
Biochemical mechanisms with mass action kinetics are often modeled by systems of polynomial differential equations (DE). Determining directly if the DE system has multiple equilibria (multistationarity) is difficult for realistic systems, since they
Alzheimers disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a num
The protein-protein interaction (PPI) network is crucial for cellular information processing and decision-making. With suitable inputs, PPI networks drive the cells to diverse functional outcomes such as cell proliferation or cell death. Here we char