ترغب بنشر مسار تعليمي؟ اضغط هنا

Biomedical Convergence Facilitated by the Emergence of Technological and Informatic Capabilities

144   0   0.0 ( 0 )
 نشر من قبل Alexander Petersen
 تاريخ النشر 2021
  مجال البحث الهندسة المعلوماتية
والبحث باللغة English




اسأل ChatGPT حول البحث

We analyzed Medical Subject Headings (MeSH) from 21.6 million research articles indexed by PubMed to map this vast space of entities and their relations, providing insights into the origins and future of biomedical convergence. Detailed analysis of MeSH co-occurrence networks identifies three robust knowledge clusters: the vast universe of microscopic biological entities and structures; systems, disease and diagnostics; and emergent biological and social phenomena underlying the complex problems driving the health, behavioral and brain science frontiers. These domains integrated from the 1990s onward by way of technological and informatic capabilities that introduced highly controllable, scalable and permutable research processes and invaluable imaging techniques for illuminating fundamental structure-function-behavior questions. Article-level analysis confirms a positive relationship between team size and topical diversity, and shows convergence to be increasing in prominence but with recent saturation. Together, our results invite additional policy support for cross-disciplinary team assembly to harness transdisciplinary convergence.



قيم البحث

اقرأ أيضاً

We develop a model of innovation that enables us to trace the interplay among three key dimensions of the innovation process: (i) demand of and (ii) supply for innovation, and (iii) technological capabilities available to generate innovation in the f orms of products, processes, and services. Building on triple helix research, we use entropy statistics to elaborate an indicator of mutual information among these dimensions that can provide indication of reduction of uncertainty. To do so, we focus on the medical context, where uncertainty poses significant challenges to the governance of innovation. We use the Medical Subject Headings (MeSH) of MEDLINE/PubMed to identify publications classified within the categories Diseases (C), Drugs and Chemicals (D), Analytic, Diagnostic, and Therapeutic Techniques and Equipment (E) and use these as knowledge representations of demand, supply, and technological capabilities, respectively. Three case-studies of medical research areas are used as representative entry perspectives of the medical innovation process. These are: (i) human papilloma virus, (ii) RNA interference, and (iii) magnetic resonance imaging. We find statistically significant periods of synergy among demand, supply, and technological capabilities (C-D-E) that point to three-dimensional interactions as a fundamental perspective for the understanding and governance of the uncertainty associated with medical innovation. Among the pairwise configurations in these contexts, the demand-technological capabilities (C-E) provided the strongest link, followed by the supply-demand (D-C) and the supply-technological capabilities (D-E) channels.
To address complex problems, scholars are increasingly faced with challenges of integrating diverse knowledge domains. We analyzed the evolution of this convergence paradigm in the broad ecosystem of brain science, which provides a real-time testbed for evaluating two modes of cross-domain integration - subject area exploration via expansive learning and cross-disciplinary collaboration among domain experts. We show that research involving both modes features a 16% citation premium relative to a mono-disciplinary baseline. Further comparison of research integrating neighboring versus distant research domains shows that the cross-disciplinary mode is essential for integrating across relatively large disciplinary distances. Yet we find research utilizing cross-domain subject area exploration alone - a convergence shortcut - to be growing in prevalence at roughly 3% per year, significantly faster than the alternative cross-disciplinary mode, despite being less effective at integrating domains and markedly less impactful. By measuring shifts in the prevalence and impact of different convergence modes in the 5-year intervals before and after 2013, our results indicate that these counterproductive patterns may relate to competitive pressures associated with global Human Brain flagship funding initiatives. Without additional policy guidance, such Grand Challenge flagships may unintentionally incentivize such convergence shortcuts, thereby undercutting the advantages of cross-disciplinary teams in tackling challenges calling on convergence.
This study aims to reveal what kind of topics emerged in the biomedical domain by retrospectively analyzing newly added MeSH (Medical Subject Headings) terms from 2001 to 2010 and how they have been used for indexing since their inclusion in the thes aurus. The goal is to investigate if the future trend of a new topic depends on what kind of topic it is without relying on external indicators such as growth, citation patterns, or word co-occurrences. This topic perspective complements the traditional publication perspective in studying emerging topics. Results show that topic characteristics, including topic category, clinical significance, and if a topic has any narrower terms at the time of inclusion, influence future popularity of a new MeSH. Four emergence trend patterns are identified, including emerged and sustained, emerged not sustained, emerged and fluctuated, and not yet emerged. Predictive models using topic characteristics for emerging topic prediction show promise. This suggests that the characteristics of topics and domain should be considered when predicting future emergence of research topics. This study bridges a gap in emerging topic prediction by offering a topic perspective and advocates for considering topic and domain characteristics as well as economic, medical, and environmental impact when studying emerging topics in the biomedical domain.
Science is a growing system, exhibiting ~4% annual growth in publications and ~1.8% annual growth in the number of references per publication. Combined these trends correspond to a 12-year doubling period in the total supply of references, thereby ch allenging traditional methods of evaluating scientific production, from researchers to institutions. Against this background, we analyzed a citation network comprised of 837 million references produced by 32.6 million publications over the period 1965-2012, allowing for a temporal analysis of the `attention economy in science. Unlike previous studies, we analyzed the entire probability distribution of reference ages - the time difference between a citing and cited paper - thereby capturing previously overlooked trends. Over this half-century period we observe a narrowing range of attention - both classic and recent literature are being cited increasingly less, pointing to the important role of socio-technical processes. To better understand the impact of exponential growth on the underlying knowledge network we develop a network-based model, featuring the redirection of scientific attention via publications reference lists, and validate the model against several empirical benchmarks. We then use the model to test the causal impact of real paradigm shifts, thereby providing guidance for science policy analysis. In particular, we show how perturbations to the growth rate of scientific output affects the reference age distribution and the functionality of the vast science citation network as an aid for the search & retrieval of knowledge. In order to account for the inflation of science, our study points to the need for a systemic overhaul of the counting methods used to evaluate citation impact - especially in the case of evaluating science careers, which can span several decades and thus several doubling periods.
We analyzed the longitudinal activity of nearly 7,000 editors at the mega-journal PLOS ONE over the 10-year period 2006-2015. Using the article-editor associations, we develop editor-specific measures of power, activity, article acceptance time, cita tion impact, and editorial renumeration (an analogue to self-citation). We observe remarkably high levels of power inequality among the PLOS ONE editors, with the top-10 editors responsible for 3,366 articles -- corresponding to 2.4% of the 141,986 articles we analyzed. Such high inequality levels suggest the presence of unintended incentives, which may reinforce unethical behavior in the form of decision-level biases at the editorial level. Our results indicate that editors may become apathetic in judging the quality of articles and susceptible to modes of power-driven misconduct. We used the longitudinal dimension of editor activity to develop two panel regression models which test and verify the presence of editor-level bias. In the first model we analyzed the citation impact of articles, and in the second model we modeled the decision time between an article being submitted and ultimately accepted by the editor. We focused on two variables that represent social factors that capture potential conflicts-of-interest: (i) we accounted for the social ties between editors and authors by developing a measure of repeat authorship among an editors article set, and (ii) we accounted for the rate of citations directed towards the editors own publications in the reference list of each article he/she oversaw. Our results indicate that these two factors play a significant role in the editorial decision process. Moreover, these two effects appear to increase with editor age, which is consistent with behavioral studies concerning the evolution of misbehavior and response to temptation in power-driven environments.
التعليقات
جاري جلب التعليقات جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا