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We propose a novel model-based approach for constructing optimal designs with complex blocking structures and network effects, for application in agricultural field experiments. The potential interference among treatments applied to different plots is described via a network structure, defined via the adjacency matrix. We consider a field trial run at Rothamsted Research and provide a comparison of optimal designs under various different models, including the commonly used designs in such situations. It is shown that when there is interference between treatments on neighbouring plots, due to the spatial arrangement of the plots, designs incorporating network effects are at least as, and often more efficient than, randomised row-column designs. The advantage of network designs is that we can construct the neighbour structure even for an irregular layout by means of a graph to address the particular characteristics of the experiment. The need for such designs arises when it is required to account for treatment-induced patterns of heterogeneity. Ignoring the network structure can lead to imprecise estimates of the treatment parameters and invalid conclusions.
We propose a method for constructing optimal block designs for experiments on networks. The response model for a given network interference structure extends the linear network effects model to incorporate blocks. The optimality criteria are chosen t
In paired comparison experiments respondents usually evaluate pairs of competing options. For this situation we introduce an appropriate model and derive optimal designs in the presence of second-order interactions when all attributes are dichotomous.
Two-stage randomized experiments are becoming an increasingly popular experimental design for causal inference when the outcome of one unit may be affected by the treatment assignments of other units in the same cluster. In this paper, we provide a m
The issue of determining not only an adequate dose but also a dosing frequency of a drug arises frequently in Phase II clinical trials. This results in the comparison of models which have some parameters in common. Planning such studies based on Baye
We define a new set of primitive operations that greatly simplify the implementation of non-blocking data structures in asynchronous shared-memory systems. The new operations operate on a set of Data-records, each of which contains multiple fields. T