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Living organisms exhibit consistent homochirality. It is argued that the specific, binary choice made is not an accident but is a consequence of parity violation in the weak interaction expressed by cosmic irradiation. The secondary muons and pairs are spin- and magnetic moment- polarized and may introduce a small, net chiral preference when they interact electromagnetically or quantum mechanically with molecules that have made the transition to self-replication. Although this preference is likely to be very small, it may suffice to give a chirally-dominant outcome after billions of replications, especially if combined with chirally-unbiased conflict between the two choices. Examples of mechanisms that can manifest the three essential steps of polarization, preference and domination are presented and some variations and possible implications are discussed.
Biological molecules chose one of two structurally, chiral systems which are related by reflection in a mirror. It is proposed that this choice was made, causally, by magnetically polarized and physically chiral cosmic-rays, which are known to have a
The investigation into the possible effects of cosmic rays on living organisms will also offer great interest. - Victor F. Hess, Nobel Lecture, December 12, 1936 High-energy radiation bursts are commonplace in our Universe. From nearby solar flares
In multi-resolution simulations, different system components are simultaneously modelled at different levels of resolution, these being smoothly coupled together. In the case of enzyme systems, computationally expensive atomistic detail is needed in
The elastic network (EN) is a prime model that describes the long-time dynamics of biomolecules. However, the use of harmonic potentials renders this model insufficient for studying large conformational changes of proteins (e.g. stretching of protein
We describe a new generation of algorithms capable of mapping the structure and conformations of macromolecules and their complexes from large ensembles of heterogeneous snapshots, and demonstrate the feasibility of determining both discrete and cont