اشترك بالحزمة الذهبية واحصل على وصول غير محدود شمرا أكاديميا
تسجيل مستخدم جديدClassification of X-Ray Protein Crystallization Using Deep Convolutional Neural Networks with a Finder Module
263
0
0.0
(
0
)
اسأل ChatGPT حول البحث
ﻻ يوجد ملخص باللغة العربية
Recently, deep convolutional neural networks have shown good results for image recognition. In this paper, we use convolutional neural networks with a finder module, which discovers the important region for recognition and extracts that region. We propose applying our method to the recognition of protein crystals for X-ray structural analysis. In this analysis, it is necessary to recognize states of protein crystallization from a large number of images. There are several methods that realize protein crystallization recognition by using convolutional neural networks. In each method, large-scale data sets are required to recognize with high accuracy. In our data set, the number of images is not good enough for training CNN. The amount of data for CNN is a serious issue in various fields. Our method realizes high accuracy recognition with few images by discovering the region where the crystallization drop exists. We compared our crystallization image recognition method with a high precision method using Inception-V3. We demonstrate that our method is effective for crystallization images using several experiments. Our method gained the AUC value that is about 5% higher than the compared method.
قيم البحث
اقرأ أيضاً
The Machine Recognition of Crystallization Outcomes (MARCO) initiative has assembled roughly half a million annotated images of macromolecular crystallization experiments from various sources and setups. Here, state-of-the-art machine learning algori
thms are trained and tested on different parts of this data set. We find that more than 94% of the test images can be correctly labeled, irrespective of their experimental origin. Because crystal recognition is key to high-density screening and the systematic analysis of crystallization experiments, this approach opens the door to both industrial and fundamental research applications.
Chromosome classification is critical for karyotyping in abnormality diagnosis. To expedite the diagnosis, we present a novel method named Varifocal-Net for simultaneous classification of chromosomes type and polarity using deep convolutional network
s. The approach consists of one global-scale network (G-Net) and one local-scale network (L-Net). It follows three stages. The first stage is to learn both global and local features. We extract global features and detect finer local regions via the G-Net. By proposing a varifocal mechanism, we zoom into local parts and extract local features via the L-Net. Residual learning and multi-task learning strategies are utilized to promote high-level feature extraction. The detection of discriminative local parts is fulfilled by a localization subnet of the G-Net, whose training process involves both supervised and weakly-supervised learning. The second stage is to build two multi-layer perceptron classifiers that exploit features of both two scales to boost classification performance. The third stage is to introduce a dispatch strategy of assigning each chromosome to a type within each patient case, by utilizing the domain knowledge of karyotyping. Evaluation results from 1909 karyotyping cases showed that the proposed Varifocal-Net achieved the highest accuracy per patient case (%) 99.2 for both type and polarity tasks. It outperformed state-of-the-art methods, demonstrating the effectiveness of our varifocal mechanism, multi-scale feature ensemble, and dispatch strategy. The proposed method has been applied to assist practical karyotype diagnosis.
Galaxy clusters appear as extended sources in XMM-Newton images, but not all extended sources are clusters. So, their proper classification requires visual inspection with optical images, which is a slow process with biases that are almost impossible
to model. We tackle this problem with a novel approach, using convolutional neural networks (CNNs), a state-of-the-art image classification tool, for automatic classification of galaxy cluster candidates. We train the networks on combined XMM-Newton X-ray observations with their optical counterparts from the all-sky Digitized Sky Survey. Our data set originates from the X-CLASS survey sample of galaxy cluster candidates, selected by a specially developed pipeline, the XAmin, tailored for extended source detection and characterisation. Our data set contains 1 707 galaxy cluster candidates classified by experts. Additionally, we create an official Zooniverse citizen science project, The Hunt for Galaxy Clusters, to probe whether citizen volunteers could help in a challenging task of galaxy cluster visual confirmation. The project contained 1 600 galaxy cluster candidates in total of which 404 overlap with the experts sample. The networks were trained on expert and Zooniverse data separately. The CNN test sample contains 85 spectroscopically confirmed clusters and 85 non-clusters that appear in both data sets. Our custom network achieved the best performance in the binary classification of clusters and non-clusters, acquiring accuracy of 90 %, averaged after 10 runs. The results of using CNNs on combined X-ray and optical data for galaxy cluster candidate classification are encouraging and there is a lot of potential for future usage and improvements.
Classification of polarimetric synthetic aperture radar (PolSAR) images is an active research area with a major role in environmental applications. The traditional Machine Learning (ML) methods proposed in this domain generally focus on utilizing hig
hly discriminative features to improve the classification performance, but this task is complicated by the well-known curse of dimensionality phenomena. Other approaches based on deep Convolutional Neural Networks (CNNs) have certain limitations and drawbacks, such as high computational complexity, an unfeasibly large training set with ground-truth labels, and special hardware requirements. In this work, to address the limitations of traditional ML and deep CNN based methods, a novel and systematic classification framework is proposed for the classification of PolSAR images, based on a compact and adaptive implementation of CNNs using a sliding-window classification approach. The proposed approach has three advantages. First, there is no requirement for an extensive feature extraction process. Second, it is computationally efficient due to utilized compact configurations. In particular, the proposed compact and adaptive CNN model is designed to achieve the maximum classification accuracy with minimum training and computational complexity. This is of considerable importance considering the high costs involved in labelling in PolSAR classification. Finally, the proposed approach can perform classification using smaller window sizes than deep CNNs. Experimental evaluations have been performed over the most commonly-used four benchmark PolSAR images: AIRSAR L-Band and RADARSAT-2 C-Band data of San Francisco Bay and Flevoland areas. Accordingly, the best obtained overall accuracies range between 92.33 - 99.39% for these benchmark study sites.
Prostate cancer is one of the most common forms of cancer and the third leading cause of cancer death in North America. As an integrated part of computer-aided detection (CAD) tools, diffusion-weighted magnetic resonance imaging (DWI) has been intens
ively studied for accurate detection of prostate cancer. With deep convolutional neural networks (CNNs) significant success in computer vision tasks such as object detection and segmentation, different CNNs architectures are increasingly investigated in medical imaging research community as promising solutions for designing more accurate CAD tools for cancer detection. In this work, we developed and implemented an automated CNNs-based pipeline for detection of clinically significant prostate cancer (PCa) for a given axial DWI image and for each patient. DWI images of 427 patients were used as the dataset, which contained 175 patients with PCa and 252 healthy patients. To measure the performance of the proposed pipeline, a test set of 108 (out of 427) patients were set aside and not used in the training phase. The proposed pipeline achieved area under the receiver operating characteristic curve (AUC) of 0.87 (95% Confidence Interval (CI): 0.84-0.90) and 0.84 (95% CI: 0.76-0.91) at slice level and patient level, respectively.
سجل دخول لتتمكن من نشر تعليقات
التعليقات
جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
