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The recently conjectured knots-quivers correspondence relates gauge theoretic invariants of a knot $K$ in the 3-sphere to representation theory of a quiver $Q_{K}$ associated to the knot. In this paper we provide geometric and physical contexts for this conjecture within the framework of the large $N$ duality of Ooguri and Vafa, that relates knot invariants to counts of holomorphic curves with boundary on $L_{K}$, the conormal Lagrangian of the knot in the resolved conifold, and corresponding M-theory considerations. From the physics side, we show that the quiver encodes a 3d ${mathcal N}=2$ theory $T[Q_{K}]$ whose low energy dynamics arises on the worldvolume of an M5 brane wrapping the knot conormal and we match the (K-theoretic) vortex partition function of this theory with the motivic generating series of $Q_{K}$. From the geometry side, we argue that the spectrum of (generalized) holomorphic curves on $L_{K}$ is generated by a finite set of basic disks. These disks correspond to the nodes of the quiver $Q_{K}$ and the linking of their boundaries to the quiver arrows. We extend this basic dictionary further and propose a detailed map between quiver data and topological and geometric properties of the basic disks that again leads to matching partition functions. We also study generalizations of A-polynomials associated to $Q_{K}$ and (doubly) refined version of LMOV invariants.
The relation between open topological strings and representation theory of symmetric quivers is explored beyond the original setting of the knot-quiver correspondence. Multiple cover generalizations of the skein relation for boundaries of holomorphic
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We conjecture a relation between generalized quiver partition functions and generating functions for symmetrically colored HOMFLY-PT polynomials and corresponding HOMFLY-PT homology Poincare polynomials of a knot $K$. We interpret the generalized qui