ترغب بنشر مسار تعليمي؟ اضغط هنا

Non-separable Models with High-dimensional Data

150   0   0.0 ( 0 )
 نشر من قبل Takuya Ura
 تاريخ النشر 2017
  مجال البحث الاحصاء الرياضي
والبحث باللغة English




اسأل ChatGPT حول البحث

This paper studies non-separable models with a continuous treatment when the dimension of the control variables is high and potentially larger than the effective sample size. We propose a three-step estimation procedure to estimate the average, quantile, and marginal treatment effects. In the first stage we estimate the conditional mean, distribution, and density objects by penalized local least squares, penalized local maximum likelihood estimation, and numerical differentiation, respectively, where control variables are selected via a localized method of L1-penalization at each value of the continuous treatment. In the second stage we estimate the average and marginal distribution of the potential outcome via the plug-in principle. In the third stage, we estimate the quantile and marginal treatment effects by inverting the estimated distribution function and using the local linear regression, respectively. We study the asymptotic properties of these estimators and propose a weighted-bootstrap method for inference. Using simulated and real datasets, we demonstrate that the proposed estimators perform well in finite samples.

قيم البحث

اقرأ أيضاً

106 - Qi Zheng , Limin Peng , Xuming He 2015
Quantile regression has become a valuable tool to analyze heterogeneous covaraite-response associations that are often encountered in practice. The development of quantile regression methodology for high-dimensional covariates primarily focuses on ex amination of model sparsity at a single or multiple quantile levels, which are typically pre-specified ad hoc by the users. The resulting models may be sensitive to the specific choices of the quantile levels, leading to difficulties in interpretation and erosion of confidence in the results. In this article, we propose a new penalization framework for quantile regression in the high-dimensional setting. We employ adaptive L1 penalties, and more importantly, propose a uniform selector of the tuning parameter for a set of quantile levels to avoid some of the potential problems with model selection at individual quantile levels. Our proposed approach achieves consistent shrinkage of regression quantile estimates across a continuous range of quantiles levels, enhancing the flexibility and robustness of the existing penalized quantile regression methods. Our theoretical results include the oracle rate of uniform convergence and weak convergence of the parameter estimators. We also use numerical studies to confirm our theoretical findings and illustrate the practical utility of our proposal
Mediation analysis has become an important tool in the behavioral sciences for investigating the role of intermediate variables that lie in the path between a randomized treatment and an outcome variable. The influence of the intermediate variable on the outcome is often explored using structural equation models (SEMs), with model coefficients interpreted as possible effects. While there has been significant research on the topic in recent years, little work has been done on mediation analysis when the intermediate variable (mediator) is a high-dimensional vector. In this work we present a new method for exploratory mediation analysis in this setting called the directions of mediation (DMs). The first DM is defined as the linear combination of the elements of a high-dimensional vector of potential mediators that maximizes the likelihood of the SEM. The subsequent DMs are defined as linear combinations of the elements of the high-dimensional vector that are orthonormal to the previous DMs and maximize the likelihood of the SEM. We provide an estimation algorithm and establish the asymptotic properties of the obtained estimators. This method is well suited for cases when many potential mediators are measured. Examples of high-dimensional potential mediators are brain images composed of hundreds of thousands of voxels, genetic variation measured at millions of SNPs, or vectors of thousands of variables in large-scale epidemiological studies. We demonstrate the method using a functional magnetic resonance imaging (fMRI) study of thermal pain where we are interested in determining which brain locations mediate the relationship between the application of a thermal stimulus and self-reported pain.
406 - Jingfei Zhang , Yi Li 2020
Though Gaussian graphical models have been widely used in many scientific fields, limited progress has been made to link graph structures to external covariates because of substantial challenges in theory and computation. We propose a Gaussian graphi cal regression model, which regresses both the mean and the precision matrix of a Gaussian graphical model on covariates. In the context of co-expression quantitative trait locus (QTL) studies, our framework facilitates estimation of both population- and subject-level gene regulatory networks, and detection of how subject-level networks vary with genetic variants and clinical conditions. Our framework accommodates high dimensional responses and covariates, and encourages covariate effects on both the mean and the precision matrix to be sparse. In particular for the precision matrix, we stipulate simultaneous sparsity, i.e., group sparsity and element-wise sparsity, on effective covariates and their effects on network edges, respectively. We establish variable selection consistency first under the case with known mean parameters and then a more challenging case with unknown means depending on external covariates, and show in both cases that the convergence rate of the estimated precision parameters is faster than that obtained by lasso or group lasso, a desirable property for the sparse group lasso estimation. The utility and efficacy of our proposed method is demonstrated through simulation studies and an application to a co-expression QTL study with brain cancer patients.
Multivariate space-time data are increasingly available in various scientific disciplines. When analyzing these data, one of the key issues is to describe the multivariate space-time dependencies. Under the Gaussian framework, one needs to propose re levant models for multivariate space-time covariance functions, i.e. matrix-valued mappings with the additional requirement of non-negative definiteness. We propose a flexible parametric class of cross-covariance functions for multivariate space-time Gaussian random fields. Space-time components belong to the (univariate) Gneiting class of space-time covariance functions, with Matern or Cauchy covariance functions in the spatial margins. The smoothness and scale parameters can be different for each variable. We provide sufficient conditions for positive definiteness. A simulation study shows that the parameters of this model can be efficiently estimated using weighted pairwise likelihood, which belongs to the class of composite likelihood methods. We then illustrate the model on a French dataset of weather variables.
Estimating causal effects for survival outcomes in the high-dimensional setting is an extremely important topic for many biomedical applications as well as areas of social sciences. We propose a new orthogonal score method for treatment effect estima tion and inference that results in asymptotically valid confidence intervals assuming only good estimation properties of the hazard outcome model and the conditional probability of treatment. This guarantee allows us to provide valid inference for the conditional treatment effect under the high-dimensional additive hazards model under considerably more generality than existing approaches. In addition, we develop a new Hazards Difference (HDi), estimator. We showcase that our approach has double-robustness properties in high dimensions: with cross-fitting, the HDi estimate is consistent under a wide variety of treatment assignment models; the HDi estimate is also consistent when the hazards model is misspecified and instead the true data generating mechanism follows a partially linear additive hazards model. We further develop a novel sparsity doubly robust result, where either the outcome or the treatment model can be a fully dense high-dimensional model. We apply our methods to study the treatment effect of radical prostatectomy versus conservative management for prostate cancer patients using the SEER-Medicare Linked Data.
التعليقات
جاري جلب التعليقات جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا