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The amount of mass loss is of fundamental importance to the lives and deaths of very massive stars, the input of chemical elements and momentum into the interstellar and intergalactic media, as well as the emitted ionizing radiation. I review mass-loss predictions for hot massive stars as a function of metal content for groups of OB stars, Luminous Blue Variables, and Wolf-Rayet stars. Although it is found that the predicted mass-loss rates drop steeply with decreasing metal content (Mdot ~ Z^{0.7-0.85}), I highlight two pieces of physics that are often overlooked: (i) mass-loss predictions for massive stars approaching the Eddington limit, and for (ii) stars that have enriched their own atmospheres with primary elements such as carbon. Both of these effects may significantly boost the mass-loss rates of the first stars - relevant for the reionization of the Universe, and a potential pre-enrichment of the intergalactic medium - prior to the first supernova explosions.
Massive stars are powerful sources of radiation, stellar winds, and supernova explosions. The radiative and mechanical energies injected by massive stars into the interstellar medium (ISM) profoundly alter the structure and evolution of the ISM, whic
The first stars form in dark matter halos of masses ~10^6 M_sun as suggested by an increasing number of numerical simulations. Radiation feedback from these stars expels most of the gas from their shallow potential well of their surrounding dark matt
The growth of the first super massive black holes (SMBHs) at z > 6 is still a major challenge for theoretical models. If it starts from black hole (BH) remnants of Population III stars (light seeds with mass ~ 100 Msun) it requires super-Eddington ac
Super-Eddington accretion onto massive black hole seeds may be commonplace in the early Universe, where the conditions exist for rapid accretion. Direct collapse black holes are often invoked as a possible solution to the observation of super massive
The young star clusters we observe today are the building blocks of a new generation of stars and planets in our Galaxy and beyond. Despite their fundamental role we still lack knowledge about the conditions under which star clusters form and the imp