ترغب بنشر مسار تعليمي؟ اضغط هنا

Individual and population approaches for calibrating division rates in population dynamics: Application to the bacterial cell cycle

49   0   0.0 ( 0 )
 نشر من قبل Marie Doumic
 تاريخ النشر 2021
  مجال البحث
والبحث باللغة English
 تأليف Marie Doumic




اسأل ChatGPT حول البحث

Modelling, analysing and inferring triggering mechanisms in population reproduction is fundamental in many biological applications. It is also an active and growing research domain in mathematical biology. In this chapter, we review the main results developed over the last decade for the estimation of the division rate in growing and dividing populations in a steady environment. These methods combine tools borrowed from PDEs and stochastic processes, with a certain view that emerges from mathematical statistics. A focus on the application to the bacterial cell division cycle provides a concrete presentation, and may help the reader to identify major new challenges in the field.

قيم البحث

اقرأ أيضاً

Molecular circadian clocks, that are found in all nucleated cells of mammals, are known to dictate rhythms of approximately 24 hours (circa diem) to many physiological processes. This includes metabolism (e.g., temperature, hormonal blood levels) and cell proliferation. It has been observed in tumor-bearing laboratory rodents that a severe disruption of these physiological rhythms results in accelerated tumor growth. The question of accurately representing the control exerted by circadian clocks on healthy and tumour tissue proliferation to explain this phenomenon has given rise to mathematical developments, which we review. The main goal of these previous works was to examine the influence of a periodic control on the cell division cycle in physiologically structured cell populations, comparing the effects of periodic control with no control, and of different periodic controls between them. We state here a general convexity result that may give a theoretical justification to the concept of cancer chronotherapeutics. Our result also leads us to hypothesize that the above mentioned effect of disruption of circadian rhythms on tumor growth enhancement is indirect, that, is this enhancement is likely to result from the weakening of healthy tissue that are at work fighting tumor growth.
160 - Jean Clairambault 2008
We study the growth rate of a cell population that follows an age-structured PDE with time-periodic coefficients. Our motivation comes from the comparison between experimental tumor growth curves in mice endowed with intact or disrupted circadian clo cks, known to exert their influence on the cell division cycle. We compare the growth rate of the model controlled by a time-periodic control on its coefficients with the growth rate of stationary models of the same nature, but with averaged coefficients. We firstly derive a delay differential equation which allows us to prove several inequalities and equalities on the growth rates. We also discuss about the necessity to take into account the structure of the cell division cycle for chronotherapy modeling. Numerical simulations illustrate the results.
Cells grown in culture act as a model system for analyzing the effects of anticancer compounds, which may affect cell behavior in a cell cycle position-dependent manner. Cell synchronization techniques have been generally employed to minimize the var iation in cell cycle position. However, synchronization techniques are cumbersome and imprecise and the agents used to synchronize the cells potentially have other unknown effects on the cells. An alternative approach is to determine the age structure in the population and account for the cell cycle positional effects post hoc. Here we provide a formalism to use quantifiable age distributions from live cell microscopy experiments to parameterize an age-structured model of cell population response.
In this article, we are interested in the analysis and simulation of solutions to an optimal control problem motivated by population dynamics issues. In order to control the spread of mosquito-borne arboviruses, the population replacement technique c onsists in releasing into the environment mosquitoes infected with the Wolbachia bacterium, which greatly reduces the transmission of the virus to the humans. Spatial releases are then sought in such a way that the infected mosquito population invades the uninfected mosquito population. Assuming very high mosquito fecundity rates, we first introduce an asymptotic model on the proportion of infected mosquitoes and then an optimal control problem to determine the best spatial strategy to achieve these releases. We then analyze this problem, including the optimality of natural candidates and carry out first numerical simulations in one dimension of space to illustrate the relevance of our approach.
Estimation of population size using incomplete lists (also called the capture-recapture problem) has a long history across many biological and social sciences. For example, human rights and other groups often construct partial and overlapping lists o f victims of armed conflicts, with the hope of using this information to estimate the total number of victims. Earlier statistical methods for this setup either use potentially restrictive parametric assumptions, or else rely on typically suboptimal plug-in-type nonparametric estimators; however, both approaches can lead to substantial bias, the former via model misspecification and the latter via smoothing. Under an identifying assumption that two lists are conditionally independent given measured covariate information, we make several contributions. First, we derive the nonparametric efficiency bound for estimating the capture probability, which indicates the best possible performance of any estimator, and sheds light on the statistical limits of capture-recapture methods. Then we present a new estimator, and study its finite-sample properties, showing that it has a double robustness property new to capture-recapture, and that it is near-optimal in a non-asymptotic sense, under relatively mild nonparametric conditions. Next, we give a method for constructing confidence intervals for total population size from generic capture probability estimators, and prove non-asymptotic near-validity. Finally, we study our methods in simulations, and apply them to estimate the number of killings and disappearances attributable to different groups in Peru during its internal armed conflict between 1980 and 2000.
التعليقات
جاري جلب التعليقات جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا