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The accuracy of medical imaging-based diagnostics is directly impacted by the quality of the collected images. A passive approach to improve image quality is one that lags behind improvements in imaging hardware, awaiting better sensor technology of acquisition devices. An alternative, active strategy is to utilize prior knowledge of the imaging system to directly post-process and improve the acquired images. Traditionally, priors about the image properties are taken into account to restrict the solution space. However, few techniques exploit the prior about the noise properties. In this paper, we propose a neural network-based model for disentangling the signal and noise components of an input noisy image, without the need for any ground truth training data. We design a unified loss function that encodes priors about signal as well as noise estimate in the form of regularization terms. Specifically, by using total variation and piecewise constancy priors along with noise whiteness priors such as auto-correlation and stationary losses, our network learns to decouple an input noisy image into the underlying signal and noise components. We compare our proposed method to Noise2Noise and Noise2Self, as well as non-local mean and BM3D, on three public confocal laser endomicroscopy datasets. Experimental results demonstrate the superiority of our network compared to state-of-the-art in terms of PSNR and SSIM.
Image denoising is the process of removing noise from noisy images, which is an image domain transferring task, i.e., from a single or several noise level domains to a photo-realistic domain. In this paper, we propose an effective image denoising met
Image restoration has seen great progress in the last years thanks to the advances in deep neural networks. Most of these existing techniques are trained using full supervision with suitable image pairs to tackle a specific degradation. However, in a
Deep convolutional networks often append additive constant (bias) terms to their convolution operations, enabling a richer repertoire of functional mappings. Biases are also used to facilitate training, by subtracting mean response over batches of tr
The effectiveness of existing denoising algorithms typically relies on accurate pre-defined noise statistics or plenty of paired data, which limits their practicality. In this work, we focus on denoising in the more common case where noise statistics
Fully supervised deep-learning based denoisers are currently the most performing image denoising solutions. However, they require clean reference images. When the target noise is complex, e.g. composed of an unknown mixture of primary noises with unk