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The possible association of the blazar TXS 0506+056 with a high-energy neutrino detected by IceCube holds the tantalizing potential to answer three astrophysical questions: 1. Where do high-energy neutrinos originate? 2. Where are cosmic rays produced and accelerated? 3. What radiation mechanisms produce the high-energy {gamma}-rays in blazars? The MeV gamma-ray band holds the key to these questions, because it is an excellent proxy for photo-hadronic processes in blazar jets, which also produce neutrino counterparts. Variability in MeV gamma-rays sheds light on the physical conditions and mechanisms that take place in the particle acceleration sites in blazar jets. In addition, hadronic blazar models also predict a high level of polarization fraction in the MeV band, which can unambiguously distinguish the radiation mechanism. Future MeV missions with a large field of view, high sensitivity, and polarization capabilities will play a central role in multi-messenger astronomy, since pointed, high-resolution telescopes will follow neutrino alerts only when triggered by an all-sky instrument.
This is a summary of a series of lectures on the current experimental and theoretical status of our understanding of origin and nature of cosmic radiation. Specific focus is put on ultra-high energy cosmic radiation above ~10^17 eV, including seconda
The core mission of the IceCube Neutrino observatory is to study the origin and propagation of cosmic rays. IceCube, with its surface component IceTop, observes multiple signatures to accomplish this mission. Most important are the astrophysical neut
The origin of the knee in cosmic ray spectrum remains to be an unsolved fundamental problem. There are various kinds of models which predict different break positions and the compositions of the knee. In this work, we suggest to use diffuse $gamma$-r
The cores of Arp 220, the closest ultra-luminous infrared starburst galaxy, provide an opportunity to study interactions of cosmic rays under extreme conditions. In this paper, we model the populations of cosmic rays produced by supernovae in the cen
We investigate the shock acceleration of particles in massive galaxy mergers or collisions, and show that cosmic rays (CRs) can be accelerated up to the second knee energy ~0.1-1 EeV and possibly beyond, with a hard spectral index Gamma ~ 2. Such CRs