ترغب بنشر مسار تعليمي؟ اضغط هنا

An external validation of Thais cardiovascular 10-year risk assessment in the southern Thailand

45   0   0.0 ( 0 )
 نشر من قبل Sipat Triukose
 تاريخ النشر 2018
  مجال البحث الاحصاء الرياضي
والبحث باللغة English




اسأل ChatGPT حول البحث

Cardiovascular diseases (CVDs) is a number one cause of death globally. WHO estimated that CVD is a cause of 17.9 million deaths (or 31% of all global deaths) in 2016. It may seem surprising, CVDs can be easily prevented by altering lifestyle to avoid risk factors. The only requirement needed is to know your risk prior. Thai CV Risk score is a trustworthy tool to forecast risk of having cardiovascular event in the future for Thais. This study is an external validation of the Thai CV risk score. We aim to answer two key questions. Firstly, Can Thai CV Risk score developed using dataset of people from central and north western parts of Thailand is applicable to people from other parts of the country? Secondly, Can Thai CV Risk score developed for general public works for hospitals patients who tend to have higher risk? We answer these two questions using a dataset of 1,025 patients (319 males, 35-70 years old) from Lansaka Hospital in the southern Thailand. In brief, we find that the Thai CV risk score works for southern Thais population including patients in the hospital. It generally works well for low CV risk group. However, the score tends to overestimate moderate and high risks. Fortunately, this poses no serious concern for general public as it only makes people be more careful about their lifestyle. The doctor should be careful when using the score with other factors to make treatment decision.

قيم البحث

اقرأ أيضاً

Background: Cardiovascular diseases (CVDs) are among the leading causes of death worldwide. Predictive scores providing personalised risk of developing CVD are increasingly used in clinical practice. Most scores, however, utilise a homogenous set of features and require the presence of a physician. Objective: The aim was to develop a new risk model (DiCAVA) using statistical and machine learning techniques that could be applied in a remote setting. A secondary goal was to identify new patient-centric variables that could be incorporated into CVD risk assessments. Methods: Across 466,052 participants, Cox proportional hazards (CPH) and DeepSurv models were trained using 608 variables derived from the UK Biobank to investigate the 10-year risk of developing a CVD. Data-driven feature selection reduced the number of features to 47, after which reduced models were trained. Both models were compared to the Framingham score. Results: The reduced CPH model achieved a c-index of 0.7443, whereas DeepSurv achieved a c-index of 0.7446. Both CPH and DeepSurv were superior in determining the CVD risk compared to Framingham score. Minimal difference was observed when cholesterol and blood pressure were excluded from the models (CPH: 0.741, DeepSurv: 0.739). The models show very good calibration and discrimination on the test data. Conclusion: We developed a cardiovascular risk model that has very good predictive capacity and encompasses new variables. The score could be incorporated into clinical practice and utilised in a remote setting, without the need of including cholesterol. Future studies will focus on external validation across heterogeneous samples.
This paper investigates the use of extreme value theory for modelling the distribution of demand-net-of-wind for capacity adequacy assessment. Extreme value theory approaches are well-established and mathematically justified methods for estimating th e tails of a distribution and so are ideally suited for problems in capacity adequacy, where normally only the tails of the relevant distributions are significant. The extreme value theory peaks over threshold approach is applied directly to observations of demand-net-of-wind, meaning that no assumption is needed about the nature of any dependence between demand and wind. The methodology is tested on data from Great Britain and compared to two alternative approaches: use of the empirical distribution of demand-net-of-wind and use of a model which assumes independence between demand and wind. Extreme value theory is shown to produce broadly similar estimates of risk metrics to the use of the above empirical distribution but with smaller sampling uncertainty. Estimates of risk metrics differ when the approach assuming independence is used, especially when data across different historical years are pooled, suggesting that assuming independence might result in the over- or under-estimation of risk metrics.
Using the action sequence data (i.e., log data) from the problem-solving in technology-rich environments assessment on the 2012 Programme for the International Assessment of Adult Competencies survey, the current study examines the associations betwe en adult digital problem-solving behavior and several demographic and cognitive variables. Action sequence features extracted using multidimensional scaling (Tang, Wang, He, Liu, & Ying, 2019) and sequence-to-sequence autoencoders (Tang, Wang, Liu, & Ying, 2019) were used to predict test-taker external characteristics. Features extracted from action sequences were consistently found to contain more information on demographic and cognitive characteristics than final scores. Partial least squares analyses further revealed systematic associations between behavioral patterns and demographic/cognitive characteristics.
Guidelines for the management of atherosclerotic cardiovascular disease (ASCVD) recommend the use of risk stratification models to identify patients most likely to benefit from cholesterol-lowering and other therapies. These models have differential performance across race and gender groups with inconsistent behavior across studies, potentially resulting in an inequitable distribution of beneficial therapy. In this work, we leverage adversarial learning and a large observational cohort extracted from electronic health records (EHRs) to develop a fair ASCVD risk prediction model with reduced variability in error rates across groups. We empirically demonstrate that our approach is capable of aligning the distribution of risk predictions conditioned on the outcome across several groups simultaneously for models built from high-dimensional EHR data. We also discuss the relevance of these results in the context of the empirical trade-off between fairness and model performance.
The burden of depression and anxiety in the world is rising. Identification of individuals at increased risk of developing these conditions would help to target them for prevention and ultimately reduce the healthcare burden. We developed a 10-year p redictive algorithm for depression and anxiety using the full cohort of over 400,000 UK Biobank (UKB) participants without pre-existing depression or anxiety using digitally obtainable information. From the initial 204 variables selected from UKB, processed into > 520 features, iterative backward elimination using Cox proportional hazards model was performed to select predictors which account for the majority of its predictive capability. Baseline and reduced models were then trained for depression and anxiety using both Cox and DeepSurv, a deep neural network approach to survival analysis. The baseline Cox model achieved concordance of 0.813 and 0.778 on the validation dataset for depression and anxiety, respectively. For the DeepSurv model, respective concordance indices were 0.805 and 0.774. After feature selection, the depression model contained 43 predictors and the concordance index was 0.801 for both Cox and DeepSurv. The reduced anxiety model, with 27 predictors, achieved concordance of 0.770 in both models. The final models showed good discrimination and calibration in the test datasets.We developed predictive risk scores with high discrimination for depression and anxiety using the UKB cohort, incorporating predictors which are easily obtainable via smartphone. If deployed in a digital solution, it would allow individuals to track their risk, as well as provide some pointers to how to decrease it through lifestyle changes.
التعليقات
جاري جلب التعليقات جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا