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Modeling the growth of organisms validates a general relation between metabolic costs and natural selection

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 نشر من قبل Michael Hinczewski
 تاريخ النشر 2018
  مجال البحث علم الأحياء فيزياء
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Metabolism and evolution are closely connected: if a mutation incurs extra energetic costs for an organism, there is a baseline selective disadvantage that may or may not be compensated for by other adaptive effects. A long-standing, but to date unproven, hypothesis is that this disadvantage is equal to the fractional cost relative to the total resting metabolic expenditure. This hypothesis has found a recent resurgence as a powerful tool for quantitatively understanding the strength of selection among different classes of organisms. Our work explores the validity of the hypothesis from first principles through a generalized metabolic growth mode



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