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تسجيل مستخدم جديدPut the odds on your side: a new measure for epidemiological associations
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The odds ratio (OR) is a measure of effect size commonly used in observational research. OR reflects statistical association between a binary outcome, such as the presence of a health condition, and a binary predictor, such as an exposure to a pollutant. Statistical inference and interval estimation for OR are often performed on the logarithmic scale, due to asymptotic convergence of log(OR) to a normal distribution. Here, we propose a new normalized measure of effect size, $gamma$, and derive its asymptotic distribution. We show that the new statistic, based on the $gamma$ distribution, is more powerful than the traditional one for testing the hypothesis $H_0$: log(OR)=0. The new normalized effect size is termed `gamma prime in the spirit of $D$, a normalized measure of genetic linkage disequilibrium, which ranges from -1 to 1 for a pair of genetic loci. The normalization constant for $gamma$ is based on the maximum range of the standardized effect size, for which we establish a peculiar connection to the Laplace Limit Constant. Furthermore, while standardized effects are of little value on their own, we propose a powerful application, in which standardized effects are employed as an intermediate step in an approximate, yet accurate posterior inference for raw effect size measures, such as log(OR) and $gamma$.
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The odds ratio measure is used in health and social surveys where the odds of a certain event is to be compared between two populations. It is defined using logistic regression, and requires that data from surveys are accompanied by their weights. A
nonparametric estimation method that incorporates survey weights and auxiliary information may improve the precision of the odds ratio estimator. It consists in $B$-spline calibration which can handle the nonlinear structure of the parameter. The variance is estimated through linearization. Implementation is possible through standard survey softwares. The gain in precision depends on the data as shown on two examples.
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The odds ratio (OR) is a widely used measure of the effect size in observational research. ORs reflect statistical association between a binary outcome, such as the presence of a health condition, and a binary predictor, such as an exposure to a poll
utant. Statistical significance and interval estimates are often computed for the logarithm of OR, ln(OR), and depend on the asymptotic standard error of ln(OR). For a sample of size N, the standard error can be written as a ratio of sigma over square root of N, where sigma is the population standard deviation of ln(OR). The ratio of ln(OR) over sigma is a standardized effect size. Unlike correlation, that is another familiar standardized statistic, the standardized ln(OR) cannot reach values of minus one or one. We find that its maximum possible value is given by the Laplace Limit Constant, (LLC=0.6627...), that appears as a condition in solutions to Kepler equation -- one of the central equations in celestial mechanics. The range of the standardized ln(OR) is bounded by minus LLC to LLC, reaching its maximum for ln(OR)~4.7987. This range has implications for analysis of epidemiological associations, affecting the behavior of the reasonable prior distribution for the standardized ln(OR).
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