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General pulsed-field gradient signal attenuation expression based on a fractional integral modified-Bloch equation

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 نشر من قبل Guoxing Lin
 تاريخ النشر 2017
  مجال البحث فيزياء
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 تأليف Guoxing Lin




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Anomalous diffusion has been investigated in many polymer and biological systems. The analysis of PFG anomalous diffusion relies on the ability to obtain the signal attenuation expression. However, the general analytical PFG signal attenuation expression based on the fractional derivative has not been previously reported. Additionally, the reported modified-Bloch equations for PFG anomalous diffusion in the literature yielded different results due to their different forms. Here, a new integral type modified-Bloch equation based on the fractional derivative for PFG anomalous diffusion is proposed, which is significantly different from the conventional differential type modified-Bloch equation. The merit of the integral type modified-Bloch equation is that the original properties of the contributions from linear or nonlinear processes remain unchanged at the instant of the combination. From the modified-Bloch equation, the general solutions are derived, which includes the finite gradient pulse width (FGPW) effect. The numerical evaluation of these PFG signal attenuation expressions can be obtained either by the Adomian decomposition, or a direct integration method that is fast and practicable. The theoretical results agree with the continuous-time random walk (CTRW) simulations performed in this paper. Additionally, the relaxation effect in PFG anomalous diffusion is found to be different from that in PFG normal diffusion. The new modified-Bloch equations and their solutions provide a fundamental tool to analyze PFG anomalous diffusion in nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI).



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57 - Guoxing Lin 2017
Anomalous diffusion exists widely in polymer and biological systems. Pulsed-field gradient (PFG) anomalous diffusion is complicated, especially in the anisotropic case where limited research has been reported. An general PFG signal attenuation expres sion, including the finite gradient pulse (FGPW) effect for free general anisotropic fractional diffusion based on the fractional derivative, has not been obtained, where {alpha} and b{eta} are time and space derivative orders. It is essential to derive a general PFG signal attenuation expression including the FGPW effect for PFG anisotropic anomalous diffusion research. In this paper, two recently developed modified-Bloch equations, the fractal differential modified-Bloch equation and the fractional integral modified-Bloch equation, were extended to obtain general PFG signal attenuation expressions for anisotropic anomalous diffusion. Various cases of PFG anisotropic anomalous diffusion were investigated, including coupled and uncoupled anisotropic anomalous diffusion. The continuous-time random walk (CTRW) simulation was also carried out to support the theoretical results. There is good agreement between the theory and the CTRW simulation. The obtained signal attenuation expressions and the three-dimensional fractional modified-Bloch equations are important for analyzing PFG anisotropic anomalous diffusion in NMR and MRI.
85 - Guoxing Lin 2017
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150 - Guoxing Lin 2017
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78 - Guoxing Lin 2016
Pulsed field gradient (PFG) has been increasingly employed to study anomalous diffusions in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI). However, the analysis of PFG anomalous diffusion is complicated. In this paper, a fract al derivative model based modified Gaussian phase distribution method is proposed to describe PFG anomalous diffusion. By using the phase distribution obtained from the effective phase shift diffusion method based on fractal derivatives, and employing some of the traditional Gaussian phase distribution approximation techniques, a general signal attenuation expression for free fractional diffusion is derived. This expression describes a stretched exponential function based attenuation, which is distinct from both the exponential attenuation for normal diffusion obtained from conventional Gaussian phase distribution approximation, and the Mittag-Leffler function based attenuation for anomalous diffusion obtained from fractional derivative. The obtained signal attenuation expression can analyze the finite gradient pulse width (FGPW) effect. Additionally, it can generally be applied to all three types of PFG fractional diffusions classified based on time derivative order alpha and space derivative order beta. These three types of fractional diffusions include time-fractional diffusion, space-fractional diffusion, and general fractional diffusion. The results in this paper are consistent with reported results based on effective phase shift diffusion equation method and instantaneous signal attenuation method. This method provides a new, convenient approximation formalism for analyzing PFG anomalous diffusion experiments.
67 - Guoxing Lin 2016
Anomalous diffusion exists widely in polymer and biological systems. Pulsed field gradient (PFG) techniques have been increasingly used to study anomalous diffusion in NMR and MRI. However, the interpretation of PFG anomalous diffusion is complicated . Moreover, there is not an exact signal attenuation expression based on fractional derivatives for PFG anomalous diffusion, which includes the finite gradient pulse width effect. In this paper, a new method, a Mainardi-Luchko-Pagnini (MLP) phase distribution approximation, is proposed to describe PFG fractional diffusion. MLP phase distribution is a non-Gaussian phase distribution. From the fractional diffusion equation based on fractional derivatives in both real space and phase space, the obtained probability distribution function is a MLP distribution. The MLP distribution leads to a Mittag-Leffler function based PFG signal attenuation rather than the exponential or stretched exponential attenuation that is obtained from a Gaussian phase distribution (GPD) under a short gradient pulse approximation. The MLP phase distribution approximation is employed to get a complete signal attenuation expression E{alpha}(-Dfb*{alpha},b{eta}) that includes the finite gradient pulse width effect for all three types of PFG fractional diffusion. The results obtained in this study are in agreement with the results from the literature. These results provide a new, convenient approximation formalism to interpret complex PFG fractional diffusion experiments.
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