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Recently, the structural controllability theory has been introduced to analyze the Protein-Protein Interaction (PPI) network. The indispensable nodes, which their removal increase the number of driver nodes to control the network, are found essential in PPI network. However, the PPI network is far from complete and there may exist many false-positive or false-negative interactions, which promotes us to question: are these indispensable nodes robust to structural change? Here we systematically investigate the robustness of indispensable nodes of PPI network by removing and adding possible interactions. We found that the indispensable nodes are sensitive to the structural change and very few edges can change the type of many indispensable nodes. The finding may promote our understanding to the control principle of PPI network.
Motivation: High-throughput experimental techniques have been producing more and more protein-protein interaction (PPI) data. PPI network alignment greatly benefits the understanding of evolutionary relationship among species, helps identify conserve
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