اشترك بالحزمة الذهبية واحصل على وصول غير محدود شمرا أكاديميا
تسجيل مستخدم جديدDisrupting the wall accumulation of human sperm cells by artificial corrugation
90
0
0.0
(
0
)
اسأل ChatGPT حول البحث
ﻻ يوجد ملخص باللغة العربية
Many self-propelled microorganisms are attracted to surfaces. This makes their dynamics in restricted geometries very different from that observed in the bulk. Swimming along walls is beneficial for directing and sorting cells, but may be detrimental if homogeneous populations are desired, such as in counting microchambers. In this work, we characterize the motion of human sperm cells $60 mu m$ long, strongly confined to $25 mu m$ shallow chambers. We investigate the nature of the cell trajectories between the confining surfaces and their accumulation near the borders. Observed cell trajectories are composed of a succession of quasi-circular and quasi-linear segments. This suggests that the cells follow a path of intermittent trappings near the top and bottom surfaces separated by stretches of quasi-free motion in between the two surfaces, as confirmed by depth resolved confocal microscopy studies. We show that the introduction of artificial petal-shaped corrugation in the lateral boundaries removes the tendency of cells to accumulate near the borders, an effect which we hypothesize may be valuable for microfluidic applications in biomedicine.
قيم البحث
اقرأ أيضاً
The guidance of human sperm cells under confinement in quasi 2D microchambers is investigated using a purely physical method to control their distribution. Transport property measurements and simulations are performed with dilute sperm populations, f
or which effects of geometrical guidance and concentration are studied in detail. In particular, a trapping transition at convex angular wall features is identified and analyzed. We also show that highly efficient microratchets can be fabricated by using curved asymmetric obstacles to take advantage of the spermatozoa specific swimming strategy.
We briefly describe the similarities of the experiments of sperm motion in microfluidic strictures by Zafeeani et al. in 2019 (Sci. Adv. 5, eaav21111, 2019) and those by Altshuler et al. in 2013 (Soft Matter 9, 1864, 2013). We shortly discuss the hyd
rodynamic elements justifying the strong resemblance between the two types of experiments, and suggest that other previous results in E. coli motion (Soft Matter 11, 6248, 2015) may shed further light on the understanding of sperm migration.
As a natural and functional behavior, various microorganisms exhibit gravitaxis by orienting and swimming upwards against gravity. Swimming autophoretic nanomotors described herein, comprising bimetallic nanorods, preferentially orient upwards and sw
im up along a wall, when tail-heavy (i.e. when the density of one of the metals is larger than the other). Through experiment and theory, two mechanisms were identified that contribute to this gravitactic behavior. First, a buoyancy or gravitational torque acts on these rods to align them upwards. Second, hydrodynamic interactions of the rod with the inclined wall induce a fore-aft drag asymmetry on the rods that reinforces their orientation bias and promotes their upward motion.
We consider adiabatic superconducting cells operating as an artificial neuron and synapse of a multilayer perceptron (MLP). Their compact circuits contain just one and two Josephson junctions, respectively. While the signal is represented as magnetic
flux, the proposed cells are inherently nonlinear and close-to-linear magnetic flux transformers. The neuron is capable of providing a one-shot calculation of sigmoid and hyperbolic tangent activation functions most commonly used in MLP. The synapse features by both positive and negative signal transfer coefficients in the range ~ (-0.5,0.5). We briefly discuss implementation issues and further steps toward multilayer adiabatic superconducting artificial neural network which promises to be a compact and the most energy-efficient implementation of MLP.
The motion of soft-glassy materials (SGM) in a confined geometry is strongly impacted by surface roughness. However, the effect of the spatial distribution of the roughness remains poorly understood from a more quantitative viewpoint. Here we present
a comprehensive study of concentrated emulsions flowing in microfluidic channels, one wall of which is patterned with micron-size equally spaced grooves oriented perpendicularly to the flow direction. We show that roughness-induced fluidization can be quantitatively tailored by systematically changing both the width and separation of the grooves. We find that a simple scaling law describes such fluidization as a function of the density of grooves, suggesting common scenarios for droplet trapping and release. Numerical simulations confirm these views and are used to elucidate the relation between fluidization and the rate of plastic rearrangements.
سجل دخول لتتمكن من نشر تعليقات
التعليقات
جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
