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In this paper, we discuss limits on various astro-particle scenarios if the scale textit{and} the reheat temperature of the last relevant inflation were very high. While the observed B like pattern of polarizations of the CMB suggest a very high ($ge 10^{16} GeV$) scale of a primordial (which motivated this work initially) and may reflect effects of dust, we believe that addressing these issues is nonetheless very useful. We recall the potential difficulties with various topological defects - monopoles, strings and domain walls generated at the SSB (spontaneous symmetry breaking) of various gauge symmetries. The main part of the paper is devoted to discussing difficulties with long-lived heavy particles, which could be dark matter but cannot efficiently annihilate to the required residual density because of basic S-Matrix unitarity/analyticity limits. We indicate in simple terms yet in some detail how the WIMP miracle occurs at $M(X)sim{TeV}$ and how the axiomatic upper bound presently updated to $M(X) le{110 TeV}$ was originally derived by Greist and Kamionokowski. We also argue that generically we expect the stronger $M(X)le{20 GeV}$ bound to hold. We then elaborate on the pure particle physics approaches aiming to enhance the annihilation and evade the bounds. We find that the only and in fact very satisfactory way of doing this requires endowing the particles with gauge interactions with a confinement scale lower than $M(X)$. We also comment on models with light $O(KeV)$ dark matter, which was supposed to be frozen in via out-of equilibrium processes so as to have the right relic densities pointing out that in many such cases textit{very} low reheat temperatures are indeed required and speculate on the large desert scenario of particle physics. Most of what we discuss is not new but was not presented in a coherent fashion.
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